About the Authors

Woong Y. Hwang

Contributed equally to this work with: Woong Y. Hwang, Yanfang Fu

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Yanfang Fu

Contributed equally to this work with: Woong Y. Hwang, Yanfang Fu

Affiliations Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

Deepak Reyon

Affiliations Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

Morgan L. Maeder

Affiliation Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Prakriti Kaini

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Jeffry D. Sander

Affiliations Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

J. Keith Joung

Affiliations Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

Randall T. Peterson

jyeh1@partners.org (JY); peterson@cvrc.mgh.harvard.edu (RTP)

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

Jing-Ruey Joanna Yeh

jyeh1@partners.org (JY); peterson@cvrc.mgh.harvard.edu (RTP)

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

One of the authors, JKJ has a financial interest in Transposagen Biopharmaceuticals. JKJs interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WYH YF DR MLM JDS JKJ RTP JRJY. Performed the experiments: WYH YF DR MLM PK. Analyzed the data: WYH YF DR MLM PK JDS JKJ RTP JRJY. Contributed reagents/materials/analysis tools: WYH YF DR MLM JDS. Wrote the paper: WYH YF DR MLM JDS JKJ RTP JRJY.