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Research Article

Estimation of HIV Incidence in a Large, Community-Based, Randomized Clinical Trial: NIMH Project Accept (HIV Prevention Trials Network 043)

  • Oliver Laeyendecker equal contributor,

    equal contributor Contributed equally to this work with: Oliver Laeyendecker, Estelle Piwowar-Manning

    Affiliations: Laboratory of Immunoregulation, NIAID, NIH, Baltimore, Maryland, United States of America, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Estelle Piwowar-Manning equal contributor,

    equal contributor Contributed equally to this work with: Oliver Laeyendecker, Estelle Piwowar-Manning

    Affiliation: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Agnes Fiamma,

    Affiliation: Program in Global Health, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Michal Kulich,

    Affiliation: Department of Probability and Statistics, Faculty of Mathematics and Physics, Charles University in Prague, Prague, Czech Republic

    X
  • Deborah Donnell,

    Affiliations: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America

    X
  • Deb Bassuk,

    Affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Caroline E. Mullis,

    Affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    Current address: Georgetown University, Washington, D.C., United States of America

    X
  • Craig Chin,

    Affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Priscilla Swanson,

    Affiliation: Infectious Diseases Research, Abbott Diagnostics, Abbott Park, Illinois, United States of America

    X
  • John Hackett Jr,

    Affiliation: Infectious Diseases Research, Abbott Diagnostics, Abbott Park, Illinois, United States of America

    X
  • William Clarke,

    Affiliation: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Mark Marzinke,

    Affiliation: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Greg Szekeres,

    Affiliation: Program in Global Health, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Glenda Gray,

    Affiliation: Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital/University of the Witwatersrand, Johannesburg, South Africa

    X
  • Linda Richter,

    Affiliation: Human Sciences Research Council, Durban, South Africa

    X
  • Michel W. Alexandre,

    Affiliation: Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

    X
  • Suwat Chariyalertsak,

    Affiliation: Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand

    X
  • Alfred Chingono,

    Affiliation: Department of Psychiatry, School of Medicine, University of Zimbabwe, Harare, Zimbabwe

    X
  • David D. Celentano,

    Affiliation: Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • Stephen F. Morin,

    Affiliation: Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Michael Sweat,

    Affiliation: Department of Psychiatry and Behavioral Sciences, The Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Thomas Coates,

    Affiliation: Program in Global Health, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Susan H. Eshleman mail

    seshlem@jhmi.edu

    Affiliation: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Published: July 11, 2013
  • DOI: 10.1371/journal.pone.0068349

About the Authors

Oliver Laeyendecker
Laboratory of Immunoregulation, NIAID, NIH, Baltimore, Maryland, United States of America
Oliver Laeyendecker, Caroline E. Mullis
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Estelle Piwowar-Manning, William Clarke, Mark Marzinke, Susan H. Eshleman
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Agnes Fiamma, Greg Szekeres, Thomas Coates
Program in Global Health, University of California Los Angeles, Los Angeles, California, United States of America
Michal Kulich
Department of Probability and Statistics, Faculty of Mathematics and Physics, Charles University in Prague, Prague, Czech Republic
Deborah Donnell, Deb Bassuk, Craig Chin
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Deborah Donnell
Department of Global Health, University of Washington, Seattle, Washington, United States of America
Priscilla Swanson, John Hackett Jr
Infectious Diseases Research, Abbott Diagnostics, Abbott Park, Illinois, United States of America
Glenda Gray
Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital/University of the Witwatersrand, Johannesburg, South Africa
Linda Richter
Human Sciences Research Council, Durban, South Africa
Michel W. Alexandre
Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
Suwat Chariyalertsak
Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand
Alfred Chingono
Department of Psychiatry, School of Medicine, University of Zimbabwe, Harare, Zimbabwe
David D. Celentano
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Stephen F. Morin
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Michael Sweat
Department of Psychiatry and Behavioral Sciences, The Medical University of South Carolina, Charleston, South Carolina, United States of America

Corresponding Author

Email: seshlem@jhmi.edu

Competing Interests

The authors declare that they do not have a commercial or other association that might pose a conflict of interest, with the following exceptions: PS and JH are employees and stockholders of Abbott Laboratories, manufacturer of the HIV Combo assay. Abbott Laboratories provided HIV Combo assay testing for this study. Dr. SHE received an honorarium in 2009 for an invited presentation at a symposium sponsored by Abbott Laboratories and has collaborated with investigators at Abbott Laboratories on research projects. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: OL EPM MK DD DB WC MS TC SHE. Performed the experiments: CEM CC. Analyzed the data: OL EPM AF MK DD DB CEM CC PS JH WC MM. Contributed reagents/materials/analysis tools: GS GG LR SC AC DC SFM. Wrote the paper: OL EPM AF MK DD TC SHE. Statistical work: MK DD DB CC. Provided intellectual input into the manuscript: OL EPM AF MK DD DB CEM CC PS JH WC MM GS GG LR MA SC AC DC SFM MS TC SHE.