About the Authors

Hongjie Zhu

Contributed equally to this work with: Hongjie Zhu, Mikhail B. Bogdanov

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

Mikhail B. Bogdanov

Contributed equally to this work with: Hongjie Zhu, Mikhail B. Bogdanov

Affiliation Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York, United States of America

Stephen H. Boyle

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

Wayne Matson

Affiliation Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America

Swati Sharma

Affiliation Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America

Samantha Matson

Affiliations Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Erik Churchill

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

Oliver Fiehn

Affiliation Genome Center, University of California Davis, Davis, California, United States of America

John A. Rush

Affiliation Duke-NUS Graduate Medical School, Singapore, Singapore

Ranga R. Krishnan

Affiliations Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America, Duke-NUS Graduate Medical School, Singapore, Singapore

Eve Pickering

Affiliation Pfizer Global R&D, Clinical Research Statistics, Groton, Connecticut, United States of America

Marielle Delnomdedieu

Affiliation Pfizer Global R&D, Neuroscience Clinical Research, Groton, Connecticut, United States of America

Rima Kaddurah-Daouk

rima.kaddurahdaouk.duke.edu

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

Pharmacometabolomics Research Network

Competing Interests

Dr. Kaddurah-Daouk is an inventor on patents in the metabolomics field. She has received funding or consultancy fees for BMS, Pfizer Inc., AstraZeneca and Lundbeck. Dr. Ranga Krishnan has served as consultant for CeNeRx, Lundbeck, foundation, Pfizer Inc. He has direct and indirect ownership interest in CeNeRx, Corcept, Orexigen, Atentiv, sonexa and Protalix. Additionally he is an inventor on patents in the metabolomics field. Wayne Matson is an inventor on patents in the metabolomics field. Dr. A. Rush has received consulting fees from Advanced Neuromodulation Systems, Best Practice Project Management, Otsuka, University of Michigan and Brain Resource; has received consultant/speaker fees from Forest Pharmaceuticals and Singapore College of Family Physicians; has received consultant fees and is a stockholder of Pfizer; has received author royalties from Guilford Publications, Healthcare Technology Systems and the University of Texas Southwestern Medical Center, meeting travel grant from CINP and has received research support from the National Institute of Mental Health. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: RKD JAR RRK. Analyzed the data: HZ EC. Contributed reagents/materials/analysis tools: WM SS SM OF. Wrote the paper: RKD HZ MBB SHB. Contributed study samples: EP MD.