About the Authors

Megan L. Grove

Megan.L.Grove@uth.tmc.edu

Affiliation School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Bing Yu

Affiliation School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Barbara J. Cochran

Affiliation School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Talin Haritunians

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Joshua C. Bis

Affiliation Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America

Kent D. Taylor

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Mark Hansen

Affiliation Illumina, Inc., San Diego, California, United States of America

Ingrid B. Borecki

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

L. Adrienne Cupples

Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, Framingham Heart Study of the National, Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America

Myriam Fornage

Affiliation Institute of Molecular Medicine, Center for Human Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Vilmundur Gudnason

Affiliations Icelandic Heart Association, Research Institute, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavík, Iceland

Tamara B. Harris

Affiliation Laboratory of Population Science, National Institute on Aging, Bethesda, Maryland, United States of America

Sekar Kathiresan

Affiliations Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Robert Kraaij

Affiliation Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

Lenore J. Launer

Affiliation Laboratory of Population Science, National Institute on Aging, Bethesda, Maryland, United States of America

Daniel Levy

Affiliation Framingham Heart Study of the National, Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America

Yongmei Liu

Affiliation Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Thomas Mosley

Affiliation Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Gina M. Peloso

Affiliations Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Bruce M. Psaty

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Health Services, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Seattle, Washington, United States of America

Stephen S. Rich

Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

Fernando Rivadeneira

Affiliations Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, ErasmusAGE and Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, The Netherlands

David S. Siscovick

Affiliation Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America

Albert V. Smith

Affiliations Icelandic Heart Association, Research Institute, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavík, Iceland

Andre Uitterlinden

Affiliations ErasmusAGE and Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, The Netherlands

Cornelia M. van Duijn

Affiliations ErasmusAGE and Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, The Netherlands

James G. Wilson

Affiliation Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Christopher J. O’Donnell

Affiliations Framingham Heart Study of the National, Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Jerome I. Rotter

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Eric Boerwinkle

Affiliations School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Competing Interests

Mark Hansen is an employee of Illumina, Inc. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. All authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JCB KDT IBB LAC MF VG SK DL YL BMP SSR DSS AVS AU CMVD JGW CJO JIR EB. Performed the experiments: MLG BJC TH MH YL RK FR. Analyzed the data: MLG BY EB. Contributed reagents/materials/analysis tools: KDT IBB MF VG SK YL GMP BMP SSR DSS AVS AU CMVD JGW CJO JIR EB. Wrote the paper: MLG BY BJC TH JCB KDT MH IBB LAC MF VG TBH SK RK LJL DL YL TM GMP BMP SSR FR DSS AVS AU CMVD JGW CJO JIR EB.