Cannabinoid Receptor 2 (CB2) Plays a Role in the Generation of Germinal Center and Memory B Cells, but Not in the Production of Antigen-Specific IgG and IgM, in Response to T-dependent Antigens

Sreemanti Basu; Avijit Ray; Bonnie N. Dittel

doi:10.1371/journal.pone.0067587

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Peer-reviewed

Research Article

Cannabinoid Receptor 2 (CB2) Plays a Role in the Generation of Germinal Center and Memory B Cells, but Not in the Production of Antigen-Specific IgG and IgM, in Response to T-dependent Antigens

Sreemanti Basu ,

Contributed equally to this work with: Sreemanti Basu, Avijit Ray

Affiliations Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Avijit Ray ,

Contributed equally to this work with: Sreemanti Basu, Avijit Ray

Affiliation Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Bonnie N. Dittel

* E-mail: bonnie.dittel@bcw.edu

Affiliations Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯

Cannabinoid Receptor 2 (CB2) Plays a Role in the Generation of Germinal Center and Memory B Cells, but Not in the Production of Antigen-Specific IgG and IgM, in Response to T-dependent Antigens

Sreemanti Basu,
Avijit Ray,
Bonnie N. Dittel

Published: June 27, 2013
https://doi.org/10.1371/journal.pone.0067587

About the Authors

Sreemanti Basu

Contributed equally to this work with: Sreemanti Basu, Avijit Ray

Affiliations Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

Avijit Ray

Contributed equally to this work with: Sreemanti Basu, Avijit Ray

Affiliation Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America

Bonnie N. Dittel

* E-mail: bonnie.dittel@bcw.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SB AR BND. Performed the experiments: SB AR. Analyzed the data: SB AR BND. Contributed reagents/materials/analysis tools: SB AR BND. Wrote the paper: SB BND. Obtained permission to use the CB2-deficient mice: BND.

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B cells
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Spleen
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Plasma cells
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Immune response
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Memory B cells
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Antigen isotypes
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Enzyme-linked immunoassays
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Humoral immune response
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