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Research Article

Are All Placebo Effects Equal? Placebo Pills, Sham Acupuncture, Cue Conditioning and Their Association

  • Jian Kong mail,

    kongj@nmr.mgh.harvard.edu

    Affiliation: Psychiatry Department, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America

    X
  • Rosa Spaeth,

    Affiliation: Psychiatry Department, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America

    X
  • Amanda Cook,

    Affiliation: Psychiatry Department, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America

    X
  • Irving Kirsch,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, School of Psychology, Plymouth University, Plymouth, United Kingdom

    X
  • Brian Claggett,

    Affiliations: Division of Cardiovascular Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Biostatistics Department, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Mark Vangel,

    Affiliation: MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States of America

    X
  • Randy L. Gollub,

    Affiliation: Psychiatry Department, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America

    X
  • Jordan W. Smoller,

    Affiliation: Psychiatry Department, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America

    X
  • Ted J. Kaptchuk

    Affiliation: Program in Placebo Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: July 31, 2013
  • DOI: 10.1371/journal.pone.0067485

About the Authors

Jian Kong, Rosa Spaeth, Amanda Cook, Randy L. Gollub, Jordan W. Smoller
Psychiatry Department, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
Irving Kirsch, Ted J. Kaptchuk
Program in Placebo Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
Irving Kirsch
School of Psychology, Plymouth University, Plymouth, United Kingdom
Brian Claggett
Division of Cardiovascular Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
Brian Claggett
Biostatistics Department, Harvard School of Public Health, Boston, Massachusetts, United States of America
Mark Vangel
MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States of America

Corresponding Author

Email: kongj@nmr.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JK TK IK RG JS. Performed the experiments: JK RS. Analyzed the data: BC IK MV AC. Wrote the paper: JK AC RS TK JS.