About the Authors

Michael J. Kluk

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Todd Ashworth

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Hongfang Wang

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Birgit Knoechel

Affiliation Departments of Pediatric Hematology/Oncology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

Emily F. Mason

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Elizabeth A. Morgan

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

David Dorfman

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Geraldine Pinkus

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Oliver Weigert

Affiliation Departments of Pediatric Hematology/Oncology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

Jason L. Hornick

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Lucian R. Chirieac

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Michelle Hirsch

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

David J. Oh

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Andrew P. South

Affiliation Division of Cancer Research and Genetics Core Services Unit, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

Irene M. Leigh

Affiliation Division of Cancer Research and Genetics Core Services Unit, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

Celine Pourreyron

Affiliation Division of Cancer Research and Genetics Core Services Unit, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

Andrew J. Cassidy

Affiliation Division of Cancer Research and Genetics Core Services Unit, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

Daniel J. DeAngelo

Affiliation Departments of Pediatric Hematology/Oncology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

David M. Weinstock

Affiliation Departments of Pediatric Hematology/Oncology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

Ian E. Krop

Affiliation Departments of Pediatric Hematology/Oncology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

Deborah Dillon

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Jane E. Brock

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Alexander J. F. Lazar

Affiliation Department of Pathology, M. D. Anderson Cancer Center, Houston, Texas, United States of America

Myron Peto

Affiliation Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America

Raymond J. Cho

Affiliation Department of Dermatology, University of California, San Francisco, San Francisco, California, United States of America

Alexander Stoeck

Affiliation Merck Oncology, Boston, Massachusetts, United States of America

Brian B. Haines

Affiliation Merck Oncology, Boston, Massachusetts, United States of America

Sriram Sathayanrayanan

Affiliation Merck Oncology, Boston, Massachusetts, United States of America

Scott Rodig

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Jon C. Aster

jaster@rics.bwh.harvard.edu

Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have the following interests: Co-author Jon Aster is a consultant for Cell Signaling Technologies, maker of some of the antibody reagents described in this paper. Alexander Stoeck, Sriram Sathayanrayanan, and Brian Haines are employees of Merck Oncology. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MJK TA JCA. Performed the experiments: MJK TA HW BK OW CP AJC AS BH SS . Analyzed the data: MJK TA HW EFM EAM DD GP JLH LC MH DJO APS CP AJC DD JEB AJFL MP RJC AS BH SS SR JCA. Contributed reagents/materials/analysis tools: MJK TA HW BK EFM EAM DD GP OW JLH LC MH DJO APS IML CP AJC DJD DMW IEK DD JEB AJFL MP RJC AS BH SS SR JCA. Wrote the manuscript: MJK TA HW BK EFM EAM DD GP OW JLH LC MH DJO APS IML CP AJC DJD DMW IEK DD JEB AJFL MP RJC AS BH SS SR JCA.