About the Authors
- Michael J. Kluk
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Todd Ashworth
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Hongfang Wang
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Birgit Knoechel
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Affiliation Departments of Pediatric Hematology/Oncology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
- Emily F. Mason
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Elizabeth A. Morgan
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- David Dorfman
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Geraldine Pinkus
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Oliver Weigert
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Affiliation Departments of Pediatric Hematology/Oncology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
- Jason L. Hornick
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Lucian R. Chirieac
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Michelle Hirsch
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- David J. Oh
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Andrew P. South
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Affiliation Division of Cancer Research and Genetics Core Services Unit, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
- Irene M. Leigh
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Affiliation Division of Cancer Research and Genetics Core Services Unit, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
- Celine Pourreyron
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Affiliation Division of Cancer Research and Genetics Core Services Unit, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
- Andrew J. Cassidy
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Affiliation Division of Cancer Research and Genetics Core Services Unit, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
- Daniel J. DeAngelo
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Affiliation Departments of Pediatric Hematology/Oncology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
- David M. Weinstock
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Affiliation Departments of Pediatric Hematology/Oncology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
- Ian E. Krop
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Affiliation Departments of Pediatric Hematology/Oncology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
- Deborah Dillon
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Jane E. Brock
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Alexander J. F. Lazar
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Affiliation Department of Pathology, M. D. Anderson Cancer Center, Houston, Texas, United States of America
- Myron Peto
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Affiliation Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America
- Raymond J. Cho
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Affiliation Department of Dermatology, University of California, San Francisco, San Francisco, California, United States of America
- Alexander Stoeck
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Affiliation Merck Oncology, Boston, Massachusetts, United States of America
- Brian B. Haines
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Affiliation Merck Oncology, Boston, Massachusetts, United States of America
- Sriram Sathayanrayanan
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Affiliation Merck Oncology, Boston, Massachusetts, United States of America
- Scott Rodig
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Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Jon C. Aster
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* E-mail: jaster@rics.bwh.harvard.edu
Affiliation Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Competing Interests
The authors have the following interests: Co-author Jon Aster is a consultant for Cell Signaling Technologies, maker of some of the antibody reagents described in this paper. Alexander Stoeck, Sriram Sathayanrayanan, and Brian Haines are employees of Merck Oncology. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: MJK TA JCA. Performed the experiments: MJK TA HW BK OW CP AJC AS BH SS . Analyzed the data: MJK TA HW EFM EAM DD GP JLH LC MH DJO APS CP AJC DD JEB AJFL MP RJC AS BH SS SR JCA. Contributed reagents/materials/analysis tools: MJK TA HW BK EFM EAM DD GP OW JLH LC MH DJO APS IML CP AJC DJD DMW IEK DD JEB AJFL MP RJC AS BH SS SR JCA. Wrote the manuscript: MJK TA HW BK EFM EAM DD GP OW JLH LC MH DJO APS IML CP AJC DJD DMW IEK DD JEB AJFL MP RJC AS BH SS SR JCA.