Directed Differentiation of Human Embryonic Stem Cells into Corticofugal Neurons Uncovers Heterogeneous Fezf2-Expressing Subpopulations

Muriel Kmet; Chao Guo; Carina Edmondson; Bin Chen

doi:10.1371/journal.pone.0067292

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Open Access

Peer-reviewed

Research Article

Directed Differentiation of Human Embryonic Stem Cells into Corticofugal Neurons Uncovers Heterogeneous Fezf2-Expressing Subpopulations

Muriel Kmet,

Affiliation Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Chao Guo,

Affiliation Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Carina Edmondson,

Affiliation Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Bin Chen

* E-mail: bchen@ucsc.edu

Affiliation Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯

Directed Differentiation of Human Embryonic Stem Cells into Corticofugal Neurons Uncovers Heterogeneous Fezf2-Expressing Subpopulations

Muriel Kmet,
Chao Guo,
Carina Edmondson,
Bin Chen

Published: June 24, 2013
https://doi.org/10.1371/journal.pone.0067292

About the Authors

Muriel Kmet

Affiliation Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

Chao Guo

Affiliation Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

Carina Edmondson

Affiliation Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

Bin Chen

* E-mail: bchen@ucsc.edu

Affiliation Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MK BC. Performed the experiments: MK CG CE. Analyzed the data: MK BC. Contributed reagents/materials/analysis tools: BC. Wrote the paper: KM BC.

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Neuronal differentiation
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Neurons
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Cell differentiation
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Gene expression
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Signal inhibition
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Growth factors
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Axons
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Wnt signaling cascade
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