About the Authors
- Daniel Ness
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Affiliation Nonclinical Safety Evaluation, Elan Pharmaceuticals Inc., South San Francisco, California, United States of America
- Zhao Ren
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Affiliation Assay Development, Elan Pharmaceuticals Inc., South San Francisco, California, United States of America
- Shyra Gardai
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Affiliation Exploratory Biology, Elan Pharmaceuticals Inc., South San Francisco, California, United States of America
- Douglas Sharpnack
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Affiliation Vet Path Services Inc., Mason, Ohio, United States of America
- Victor J. Johnson
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Affiliation Burleson Research Technologies Inc. (BRT), Morrisville, North Carolina, United States of America
- Richard J. Brennan
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Affiliation Thomson Reuters Inc., Carlsbad, California, United States of America
- Elizabeth F. Brigham
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Affiliation Pharmacology, Elan Pharmaceuticals Inc., South San Francisco, California, United States of America
- Andrew J. Olaharski
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* E-mail: andrew.olaharski@gmail.com
Affiliation Nonclinical Safety Evaluation, Elan Pharmaceuticals Inc., South San Francisco, California, United States of America
Competing Interests
Daniel Ness, Zhao Ren, Shyra Gardai, Elizabeth F. Brigham, and Andrew J. Olaharski were employees of Elan Pharmaceutical where the work was conducted. Elan Pharmaceuticals funded this study. Richard J. Brennan is employed by Thomson Reuters Inc., Douglas Sharpnack by Vet Path Services Inc., and Victor J. Johnson by Burleson Research Technologies, Inc. Some work was outsourced to contract research organizations, such as Vet Path Services (Douglas Sharpnack for histopathology), Burleson Research Technologies (Victor J. Johnson for the host resistance study), and Thomson Reuters (Richard J. Brennan for pathway analysis). There are no patents, products in development or marketed products to declare. This does not alter their adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: AJO DN SG DS ZR. Performed the experiments: AJO DS EFB SG. Analyzed the data: SG VJJ AJO RJB. Contributed reagents/materials/analysis tools: SG EFB. Wrote the paper: AJO DN.