About the Authors
- Sabine Frank
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* E-mail: sabine.frank@med.uni-tuebingen.de
Affiliation Institute of Medical Psychology and Behavioral Neurobiology, fMEG Center, University of Tübingen, Tübingen, Germany
- Martin Heni
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Affiliations Department of Internal Medicine IV, University Hospital, Tübingen, Germany, German Center for Diabetes Research, Neuherberg, Germany
- Anja Moss
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Affiliation Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany
- Julia von Schnurbein
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Affiliation Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany
- Sadaf Farooqi
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Affiliation Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge, Cambridge, United Kingdom
- Hans-Ulrich Häring
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Affiliations Department of Internal Medicine IV, University Hospital, Tübingen, Germany, German Center for Diabetes Research, Neuherberg, Germany
- Andreas Fritsche
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Affiliations Department of Internal Medicine IV, University Hospital, Tübingen, Germany, German Center for Diabetes Research, Neuherberg, Germany
- Hubert Preissl
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Affiliations Institute of Medical Psychology and Behavioral Neurobiology, fMEG Center, University of Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany, German Center for Diabetes Research, Neuherberg, Germany
- Martin Wabitsch
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Affiliation Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany
Competing Interests
Amylin Pharmaceuticals, LLC (San Diego, USA) provided metreleptin for this patient under compassionate use provisions. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: S. Frank MH AM HUH AF HP MW. Performed the experiments: S. Frank MH AM JvS. Analyzed the data: S. Frank MH AM. Wrote the paper: S. Frank MH JvS HP MW. Critical revision of the manuscript: AM S. Farooqi HUH AF. Interpretation of data: AM S. Farooqi HUH AF.