About the Authors

Qing Yu

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Washington DC, United States of America

Arpana Sali

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Washington DC, United States of America

Jack Van der Meulen

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Washington DC, United States of America

Brittany K. Creeden

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Washington DC, United States of America

Heather Gordish-Dressman

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Washington DC, United States of America

Anne Rutkowski

Affiliation Kaiser SCPMG, Cure CMD, Olathe, Kansas, United States of America

Sree Rayavarapu

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Washington DC, United States of America

Kitipong Uaesoontrachoon

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Washington DC, United States of America

Tony Huynh

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Washington DC, United States of America

Kanneboyina Nagaraju

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Washington DC, United States of America

Christopher F. Spurney

cspurney@childrensnational.org

Affiliations Center for Genetic Medicine Research, Children’s National Medical Center, Washington DC, United States of America, Division of Cardiology, Children’s National Medical Center, Washington DC, United States of America

Competing Interests

The authors have the following interests. Omigapil was provided by Santhera Pharmaceuticals (Liestal, Switzerland). Thomas Meier, Chief Executive Officer for Santhera Pharmaceuticals provided comments on the manuscript. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: QY AR KN CFS. Performed the experiments: QY AS JVDM BKC SR KU TH. Analyzed the data: QY AS JVDM BKC HGD CFS SR KU TH. Contributed reagents/materials/analysis tools: QY AS JVDM BKC CFS KN SR KU TH. Wrote the paper: QY HGD AR KN CFS.