About the Authors

Nicklas Bonander

Contributed equally to this work with: Nicklas Bonander, Mohammed Jamshad, Dominik Oberthür

Affiliations School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom, Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

Mohammed Jamshad

Contributed equally to this work with: Nicklas Bonander, Mohammed Jamshad, Dominik Oberthür

Affiliation School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom

Dominik Oberthür

Contributed equally to this work with: Nicklas Bonander, Mohammed Jamshad, Dominik Oberthür

Affiliations Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, Hamburg, Germany, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany

Michelle Clare

Affiliation School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom

James Barwell

Affiliation School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom

Ke Hu

Affiliation Institute of Biomedical Research and NIHR Center for Liver Disease, University of Birmingham, Birmingham, United Kingdom

Michelle J. Farquhar

Affiliation Institute of Biomedical Research and NIHR Center for Liver Disease, University of Birmingham, Birmingham, United Kingdom

Zania Stamataki

Affiliation Institute of Biomedical Research and NIHR Center for Liver Disease, University of Birmingham, Birmingham, United Kingdom

Helen J. Harris

Affiliation Institute of Biomedical Research and NIHR Center for Liver Disease, University of Birmingham, Birmingham, United Kingdom

Karsten Dierks

Affiliation Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, Hamburg, Germany

Timothy R. Dafforn

Affiliation School of Biosciences, University of Birmingham, Birmingham, United Kingdom

Christian Betzel

Affiliation Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, Hamburg, Germany

Jane A. McKeating

Affiliation Institute of Biomedical Research and NIHR Center for Liver Disease, University of Birmingham, Birmingham, United Kingdom

Roslyn M. Bill

r.m.bill@aston.ac.uk

Affiliation School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom

Competing Interests

Michelle Clare is supported by grant BB/H016651/1 from the Biotechnology and Biological Sciences Research Council, UK, which is co-sponsored by Janssen. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NB MJ DO MC JB ZS KD CB JAM RMB. Performed the experiments: NB MJ DO MC JB KH MJF HJH. Analyzed the data: NB MJ DO MC JB JAM RMB. Contributed reagents/materials/analysis tools: TRD. Wrote the paper: NB MJ DO MC JB MJF ZS HJH JAM RMB.