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Research Article

Eosinophils Promote Epithelial to Mesenchymal Transition of Bronchial Epithelial Cells

  • Atsushi Yasukawa equal contributor,

    equal contributor Contributed equally to this work with: Atsushi Yasukawa, Koa Hosoki

    Affiliation: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Koa Hosoki equal contributor,

    equal contributor Contributed equally to this work with: Atsushi Yasukawa, Koa Hosoki

    Affiliations: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan, Institute for Clinical Research, Mie National Hospital, Tsu City, Mie, Japan

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  • Masaaki Toda,

    Affiliation: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Yasushi Miyake,

    Affiliation: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Yuki Matsushima,

    Affiliation: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Takahiro Matsumoto,

    Affiliation: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Daniel Boveda-Ruiz,

    Affiliation: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Paloma Gil-Bernabe,

    Affiliation: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Mizuho Nagao,

    Affiliation: Institute for Clinical Research, Mie National Hospital, Tsu City, Mie, Japan

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  • Mayumi Sugimoto,

    Affiliation: Institute for Clinical Research, Mie National Hospital, Tsu City, Mie, Japan

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  • Yukiko Hiraguchi,

    Affiliation: Institute for Clinical Research, Mie National Hospital, Tsu City, Mie, Japan

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  • Reiko Tokuda,

    Affiliation: Institute for Clinical Research, Mie National Hospital, Tsu City, Mie, Japan

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  • Masahiro Naito,

    Affiliation: Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Takehiro Takagi,

    Affiliation: Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Corina N. D'Alessandro-Gabazza,

    Affiliation: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Shigeru Suga,

    Affiliation: Institute for Clinical Research, Mie National Hospital, Tsu City, Mie, Japan

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  • Tetsu Kobayashi,

    Affiliation: Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Takao Fujisawa,

    Affiliation: Institute for Clinical Research, Mie National Hospital, Tsu City, Mie, Japan

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  • Osamu Taguchi,

    Affiliation: Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Esteban C. Gabazza mail

    gabazza@clin.medic.mie-u.ac.jp

    Affiliation: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

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  • Published: May 21, 2013
  • DOI: 10.1371/journal.pone.0064281

About the Authors

Atsushi Yasukawa, Koa Hosoki, Masaaki Toda, Yasushi Miyake, Yuki Matsushima, Takahiro Matsumoto, Daniel Boveda-Ruiz, Paloma Gil-Bernabe, Corina N. D'Alessandro-Gabazza, Esteban C. Gabazza
Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
Masahiro Naito, Takehiro Takagi, Tetsu Kobayashi, Osamu Taguchi
Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
Koa Hosoki, Mizuho Nagao, Mayumi Sugimoto, Yukiko Hiraguchi, Reiko Tokuda, Shigeru Suga, Takao Fujisawa
Institute for Clinical Research, Mie National Hospital, Tsu City, Mie, Japan

Corresponding Author

Email: gabazza@clin.medic.mie-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ECG TF OT. Performed the experiments: AY KH MT Y. Miyake Y. Matsushima TM DBR PG-B TK. Analyzed the data: M. Naito TT SS CND-G. Contributed reagents/materials/analysis tools: M. Nagao MS YH RT. Wrote the paper: AY CND-G.