About the Authors

Martin Zalesak

zalesakm@trinitypartners.com

Affiliation Trinity Partners, LLC, Waltham, Massachusetts, United States of America

Kevin Francis

Affiliation Trinity Partners, LLC, Waltham, Massachusetts, United States of America

Alex Gedeon

Affiliation Trinity Partners, LLC, Waltham, Massachusetts, United States of America

John Gillis

Affiliation Trinity Partners, LLC, Waltham, Massachusetts, United States of America

Kyle Hvidsten

Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

Phyllis Kidder

Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

Hong Li

Affiliation Trinity Partners, LLC, Waltham, Massachusetts, United States of America

Derek Martyn

Affiliation Trinity Partners, LLC, Waltham, Massachusetts, United States of America

Leslie Orne

Affiliation Trinity Partners, LLC, Waltham, Massachusetts, United States of America

Amanda Smith

Affiliation Trinity Partners, LLC, Waltham, Massachusetts, United States of America

Ann Kwong

Current address: InnovaTID, Cambridge, Massachusetts, United States of America

Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

Competing Interests

KH and PK are employees and stock owners of Vertex Pharmaceuticals Incorporated. AK is a former employee of Vertex Pharmaceuticals Incorporated and owned stock and options in the company at the time this research was performed. MZ, KF, AG, JG, HL, DM, LO, AS are all current or former employees of Trinity Partners, LLC, a for-profit healthcare consultancy. MZ received conference travel grants from Vertex Pharmaceuticals Incorporated to present selected portions of the data described in this manuscript. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MZ LO AK. Analyzed the data: MZ KF AG JG HL DM LO AS AK. Contributed reagents/materials/analysis tools: KF JG. Wrote the paper: MZ HL DM LO AK. Critical revision of the manuscript for important intellectual content: MZ KH PK HL DM LO AK. Obtained funding: KH AK.