About the Authors
- David Gardiner
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* E-mail: david.gardiner@bms.com
Affiliation Bristol-Myers Squibb, Pennington, New Jersey, United States of America
- Jay Lalezari
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Affiliation Quest Clinical Research, San Francisco, California, United States of America
- Eric Lawitz
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Affiliation Alamo Medical Research, San Antonio, Texas, United States of America
- Michael DiMicco
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Affiliation Advanced Clinical Research Institute, Anaheim, California, United States of America
- Rheem Ghalib
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Affiliation The Liver Institute at Methodist Hospital, Dallas, Texas, United States of America
- K. Rajender Reddy
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Affiliation University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
- Kyong-Mi Chang
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Affiliations University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America
- Mark Sulkowski
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Affiliation Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
- Steven O’ Marro
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Affiliation Springfield Clinic Infectious Diseases, Springfield, Illinois, United States of America
- Jeffrey Anderson
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Affiliation Bristol-Myers Squibb, Pennington, New Jersey, United States of America
- Bing He
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Affiliation Bristol-Myers Squibb, Pennington, New Jersey, United States of America
- Vikram Kansra
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Current address: TESARO, Waltham, Massachusetts, United States of America
Affiliation Bristol-Myers Squibb, Princeton, New Jersey, United States of America
- Fiona McPhee
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Affiliation Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Megan Wind-Rotolo
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Affiliation Bristol-Myers Squibb, Princeton, New Jersey, United States of America
- Dennis Grasela
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Affiliation Bristol-Myers Squibb, Pennington, New Jersey, United States of America
- Mark Selby
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Affiliation Bristol-Myers Squibb, Milpitas, California, United States of America
- Alan J. Korman
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Affiliation Bristol-Myers Squibb, Milpitas, California, United States of America
- Israel Lowy
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Affiliation Regeneron Pharmaceuticals, Tarrytown, New York, United States of America
Competing Interests
This study was funded by Bristol-Myers Squibb. D. Grasela, JA, BH, D. Gardiner, VK, MWR, FM, MS and AK are/were employees of, and may hold stock in, Bristol-Myers Squibb (BMS). JL is employed by Quest Clinical Research, EL by Alamo Medical Research and IL by Medarex at the time of the study. Anti-PD-1 (BMS-936558) is a patented monoclonal antibody owned by BMS and currently in Phase 3 development as treatment for patients with chronic malignancy. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: D. Gardiner IL JA BH VK FM MWR D. Grasela M. Selby AJK. Performed the experiments: EL RG M. Sulkowski JL KRR KMC MD SO VK FM MWR. Analyzed the data: D. Gardiner IL JA BH VK FM MWR M. Selby AJK. Wrote the paper: DGr. Critically reviewed and edited the manuscript for content: D. Gardiner EL MD RG KRR KMC M. Sulkowski SO JA BE VK FM MWR D. Grasela M. Selby AJK IL.