About the Authors

Ajit A. Kulkarni

Affiliations The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America, Lung Biology and Disease Program, University of Rochester, Rochester, New York, United States of America

Thomas H. Thatcher

Affiliations The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America, Lung Biology and Disease Program, University of Rochester, Rochester, New York, United States of America

Hsi-Min Hsiao

Affiliation Department of Pathology, University of Rochester, Rochester, New York, United States of America

Keith C. Olsen

Affiliations The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America, Lung Biology and Disease Program, University of Rochester, Rochester, New York, United States of America, Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America

Robert Matthew Kottmann

Affiliations The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America, Lung Biology and Disease Program, University of Rochester, Rochester, New York, United States of America

Jason Morrissette

Affiliation Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, United States of America

Terry W. Wright

Affiliations Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America, Department of Pediatrics, University of Rochester, Rochester, New York, United States of America

Richard P. Phipps

Affiliations The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America, Lung Biology and Disease Program, University of Rochester, Rochester, New York, United States of America, Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America, Department of Pediatrics, University of Rochester, Rochester, New York, United States of America, Department of Environmental Medicine, University of Rochester, Rochester New York, United States of America

Patricia J. Sime

Patricia_Sime@urmc.rochester.edu

Affiliations The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America, Lung Biology and Disease Program, University of Rochester, Rochester, New York, United States of America, Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America, Department of Environmental Medicine, University of Rochester, Rochester New York, United States of America

Competing Interests

Thomas Thatcher is an academic editor for PLOS ONE. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AAK THT KCO RPP PJS. Performed the experiments: AAK KCO HH RMK. Analyzed the data: AAK THT PJS. Contributed reagents/materials/analysis tools: PJS TWW. Wrote the paper: AAK THT RPP PJS. Statistical analysis: AAK JM. Assistance with lung function tests: TWW.