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Research Article

HIV-1 Env C2-V4 Diversification in a Slow-Progressor Infant Reveals a Flat but Rugged Fitness Landscape

  • S. Abigail Smith,

    Affiliation: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

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  • Charles Wood,

    Affiliations: Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska, United States of America, School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America

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  • John T. West mail

    john-west@ouhsc.edu

    Affiliation: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

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  • Published: April 29, 2013
  • DOI: 10.1371/journal.pone.0063094

About the Authors

S. Abigail Smith, John T. West
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
Charles Wood
Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska, United States of America
Charles Wood
School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America

Corresponding Author

Email: john-west@ouhsc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JTW. Performed the experiments: SAS. Analyzed the data: SAS JTW. Contributed reagents/materials/analysis tools: CW. Wrote the paper: SAS JTW CW.