Advertisement
Research Article

Drug-Associated Adverse Events and Their Relationship with Outcomes in Patients Receiving Treatment for Extensively Drug-Resistant Tuberculosis in South Africa

  • Karen Shean,

    Affiliation: Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa

    X
  • Elizabeth Streicher,

    Affiliation: DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Stellenbosch, South Africa

    X
  • Elize Pieterson,

    Affiliation: Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa

    X
  • Greg Symons,

    Affiliation: Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa

    X
  • Richard van Zyl Smit,

    Affiliation: Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa

    X
  • Grant Theron,

    Affiliation: Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa

    X
  • Rannakoe Lehloenya,

    Affiliation: Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa

    X
  • Xavier Padanilam,

    Affiliations: Sizwe Tropical Diseases Hospital, Sandringham, Johannesburg, South Africa, Division of Infectious Diseases, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    X
  • Paul Wilcox,

    Affiliation: Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa

    X
  • Tommie C. Victor,

    Affiliation: DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Stellenbosch, South Africa

    X
  • Paul van Helden,

    Affiliation: DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Stellenbosch, South Africa

    X
  • Martin Groubusch,

    Affiliations: Sizwe Tropical Diseases Hospital, Sandringham, Johannesburg, South Africa, National Health Laboratory Service and Division of Clinical Microbiology and Infectious Diseases, University of Witwatersrand, Johannesburg, South Africa, Division of Infectious Diseases, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, Center for Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Amsterdam Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • Robin Warren,

    Affiliation: DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Stellenbosch, South Africa

    X
  • Motasim Badri,

    Affiliations: Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

    X
  • Keertan Dheda mail

    keertan.dheda@uct.ac.za

    Affiliations: Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa, Department of Infection, University College London Medical School, London, United Kingdom

    X
  • Published: May 07, 2013
  • DOI: 10.1371/journal.pone.0063057

About the Authors

Karen Shean, Elize Pieterson, Greg Symons, Richard van Zyl Smit, Grant Theron, Rannakoe Lehloenya, Paul Wilcox, Motasim Badri, Keertan Dheda
Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
Keertan Dheda
Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Keertan Dheda
Department of Infection, University College London Medical School, London, United Kingdom
Xavier Padanilam, Martin Groubusch
Sizwe Tropical Diseases Hospital, Sandringham, Johannesburg, South Africa
Martin Groubusch
National Health Laboratory Service and Division of Clinical Microbiology and Infectious Diseases, University of Witwatersrand, Johannesburg, South Africa
Xavier Padanilam, Martin Groubusch
Division of Infectious Diseases, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Elizabeth Streicher, Tommie C. Victor, Paul van Helden, Robin Warren
DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Stellenbosch, South Africa
Martin Groubusch
Center for Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Amsterdam Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Motasim Badri
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

Corresponding Author

Email: keertan.dheda@uct.ac.za

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KS KD MB. Performed the experiments: KS KD MB. Analyzed the data: KS ES EP GS RVZS GT RL XP PW TCV PVH MG RW MB KD. Contributed reagents/materials/analysis tools: KD RW. Wrote the paper: KS ES EP GS RVZS GT RL XP PW TCV PVH MG RW MB KD.