About the Authors

Neil M. Johannsen

Contributed equally to this work with: Neil M. Johannsen, Lauren M. Sparks

Affiliations Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America, Louisiana State University, Baton Rouge, Louisiana, United States of America

Lauren M. Sparks

Contributed equally to this work with: Neil M. Johannsen, Lauren M. Sparks

Affiliation Translational Research Institute for Metabolism and Diabetes, Orlando, Florida, United States of America

Zhengyu Zhang

Affiliation Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

Conrad P. Earnest

Affiliation University of Bath, Department of Health, Bath, United Kingdom

Steven R. Smith

Affiliation Sanford-Burnham Medical Research Institute, Orlando, Florida, United States of America

Timothy S. Church

Affiliation Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

Eric Ravussin

eric.ravussin@pbrc.edu

Affiliation Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

Competing Interests

A commercial funding source is acknowledged in the manuscript: The Coca-Cola Company. The authors have no declarations for this funding source relating to employment, consultancy, patents, products in development or marketed products and the funding source does not alter their adherence to the PLOS ONE policies on sharing data and materials, as detailed in the online guide for authors.

Author Contributions

Conceived and designed the experiments: CPE SRS ER. Performed the experiments: CPE ZZ. Analyzed the data: NMJ LMS ZZ. Contributed reagents/materials/analysis tools: SRS TSC ER. Wrote the manuscript: NMJ LMS. Co-lead authors with equal contribution to writing/editing the main manuscript, researching the data, performing the statistical analysis, and preparing the manuscript for publication: NMJ LMS. Responsible for PGC-1α protein content analyses and critical editing of the manuscript: ZZ. Involved in the conception/design of the HART-D project, and performed the fitness testing of the HART-D participants and in the critique and revisions of all drafts of the main manuscript, and approved the final version: CPE. Involved in the conception/design of the ancillary project, and in the critique and revisions of all drafts of the main manuscript, and approved the final version: SRS. Obtained funding for the HART-D study and ancillary project and was responsible for medical oversight of the HART-D trial, critiqued all drafts of the manuscript, and gave approval to the final version: TSC. Involved in the concept, design, interpretation of the results of the present study and assisted with manuscript preparation: ER.