Advertisement
Research Article

Tumor Derived Mutations of Protein Tyrosine Phosphatase Receptor Type K Affect Its Function and Alter Sensitivity to Chemotherapeutics in Glioma

  • Supreet Agarwal,

    Affiliation: Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Maha S. Al-Keilani,

    Affiliation: Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Mohammad A. Y. Alqudah,

    Affiliation: Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Zita A. Sibenaller,

    Affiliation: Department of Neurosurgery and Radiation Oncology, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Timothy C. Ryken,

    Affiliations: Department of Neurosurgery and Radiation Oncology, University of Iowa, Iowa City, Iowa, United States of America, Department of Neurosurgery, Iowa Spine and Brain Institute, Waterloo, Iowa, United States of America

    X
  • Mahfoud Assem mail

    mahfoud-assem@uiowa.edu

    Affiliation: Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Published: May 16, 2013
  • DOI: 10.1371/journal.pone.0062852

About the Authors

Supreet Agarwal, Maha S. Al-Keilani, Mohammad A. Y. Alqudah, Mahfoud Assem
Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, United States of America
Zita A. Sibenaller, Timothy C. Ryken
Department of Neurosurgery and Radiation Oncology, University of Iowa, Iowa City, Iowa, United States of America
Timothy C. Ryken
Department of Neurosurgery, Iowa Spine and Brain Institute, Waterloo, Iowa, United States of America

Corresponding Author

Email: mahfoud-assem@uiowa.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MA SA. Performed the experiments: SA MSA MAYA ZS. Analyzed the data: MA SA TCR. Wrote the paper: MA SA.