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Research Article

Relaxation Response Induces Temporal Transcriptome Changes in Energy Metabolism, Insulin Secretion and Inflammatory Pathways

  • Manoj K. Bhasin equal contributor,

    equal contributor Contributed equally to this work with: Manoj K. Bhasin, Jeffery A. Dusek, Bei-Hung Chang

    Affiliations: Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, BIDMC Genomics and Proteomics Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

    X
  • Jeffery A. Dusek equal contributor,

    equal contributor Contributed equally to this work with: Manoj K. Bhasin, Jeffery A. Dusek, Bei-Hung Chang

    Affiliation: Institute for Health and Healing, Abbott Northwestern Hospital, Minneapolis, Minnesota, United States of America

    X
  • Bei-Hung Chang equal contributor,

    equal contributor Contributed equally to this work with: Manoj K. Bhasin, Jeffery A. Dusek, Bei-Hung Chang

    Affiliations: VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Health Policy and Management, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Marie G. Joseph,

    Affiliation: BIDMC Genomics and Proteomics Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

    X
  • John W. Denninger,

    Affiliations: Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Gregory L. Fricchione,

    Affiliations: Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Herbert Benson ,

    Affiliations: Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    These authors also contributed equally to this work.

    X
  • Towia A. Libermann mail

    tliberma@bidmc.harvard.edu

    Affiliations: Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, BIDMC Genomics and Proteomics Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

    These authors also contributed equally to this work.

    X
  • Published: May 01, 2013
  • DOI: 10.1371/journal.pone.0062817

About the Authors

Manoj K. Bhasin, John W. Denninger, Gregory L. Fricchione, Herbert Benson, Towia A. Libermann
Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital, Boston, Massachusetts, United States of America
John W. Denninger, Gregory L. Fricchione
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Herbert Benson
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Manoj K. Bhasin, Towia A. Libermann
Department of Medicine, Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
Manoj K. Bhasin, Marie G. Joseph, Towia A. Libermann
BIDMC Genomics and Proteomics Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
Jeffery A. Dusek
Institute for Health and Healing, Abbott Northwestern Hospital, Minneapolis, Minnesota, United States of America
Bei-Hung Chang
VA Boston Healthcare System, Boston, Massachusetts, United States of America
Bei-Hung Chang
Department of Health Policy and Management, Boston University School of Public Health, Boston, Massachusetts, United States of America

Corresponding Author

Email: tliberma@bidmc.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MKB JD HB TL. Performed the experiments: MKB MJ TL. Analyzed the data: MKB JD BC JWD GF HB TL. Contributed reagents/materials/analysis tools: MKB JD HB TL. Wrote the paper: MKB JD BC JWD GF HB TL.