About the Authors

Rong Guo

Contributed equally to this work with: Rong Guo, Yong Li

Affiliation Department of Geriatrics, Peking University First Hospital, Beijing, China

Yong Li

Contributed equally to this work with: Rong Guo, Yong Li

Affiliation Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Laboratory Animal, Peking University Cancer Hospital, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Beijing, China

Jinying Ning

Affiliation Department of Cell Biology, Crown Bioscience Incorporation (Beijing), Beijing, China

Dan Sun

Affiliation Department of Geriatrics, Peking University First Hospital, Beijing, China

Lianjun Lin

Affiliation Department of Geriatrics, Peking University First Hospital, Beijing, China

Xinmin Liu

lxm2128@163.com

Affiliation Department of Geriatrics, Peking University First Hospital, Beijing, China

Competing Interests

Dr. Jinying Ning, as the third author of this manuscript, was an employee of the company Crown Bioscience Inc (Beijing). He contributed some analysis tools and provided consultancy to this work. No patents will be shared by Crown Bioscience Inc (Beijing). No products in development and no marketed products of Crown Bioscience Inc (Beijing) were used in this research work. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: XL. Performed the experiments: RG YL. Analyzed the data: RG YL. Contributed reagents/materials/analysis tools: RG YL JN DS LL. Wrote the paper: RG YL XL.