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Research Article

Quantitative Trait Loci for Interhemispheric Commissure Development and Social Behaviors in the BTBR T+ tf/J Mouse Model of Autism

  • Dorothy M. Jones-Davis equal contributor,

    equal contributor Contributed equally to this work with: Dorothy M. Jones-Davis, Mu Yang

    Affiliation: Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

    Current address: American Association for the Advancement of Science Science and Technology Policy Fellow, The National Science Foundation, The Directorate for Engineering, Division of Engineering Education and Centers, Arlington, Virginia, United States of America

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  • Mu Yang equal contributor,

    equal contributor Contributed equally to this work with: Dorothy M. Jones-Davis, Mu Yang

    Affiliation: Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America

    Current address: MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California, United States of America

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  • Eric Rider,

    Affiliation: Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

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  • Nathan C. Osbun,

    Affiliation: Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

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  • Gilberto J. da Gente,

    Affiliation: Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

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  • Jiang Li,

    Affiliation: Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

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  • Adam M. Katz,

    Affiliation: Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Michael D. Weber,

    Affiliation: Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Saunak Sen,

    Affiliation: Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

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  • Jacqueline Crawley ,

    Affiliation: Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America

    Current address: MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California, United States of America

    These authors also contributed equally to this work.

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  • Elliott H. Sherr mail

    sherre@neuropeds.ucsf.edu

    Affiliation: Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

    These authors also contributed equally to this work.

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  • Published: April 15, 2013
  • DOI: 10.1371/journal.pone.0061829

About the Authors

Dorothy M. Jones-Davis, Eric Rider, Nathan C. Osbun, Gilberto J. da Gente, Jiang Li, Elliott H. Sherr
Department of Neurology, University of California San Francisco, San Francisco, California, United States of America
Mu Yang, Adam M. Katz, Michael D. Weber, Jacqueline Crawley
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
Saunak Sen
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: sherre@neuropeds.ucsf.edu

Competing Interests

The authors have the following interests. This work was funded in part by a grant from Pfizer, Inc. (http://www.pfizer.com) to Dr. Elliott Sherr. Dr. Mathew Pletcher (employed by Pfizer, Inc.) provided suggestions in the design and interpretation of the study, and Dr. Nicholas Brandon (employed by Pfizer, Inc.) provided a critical reading of the manuscript. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Revised the manuscript and approved the final version: DMJ-D MY ER NCO GJD JL AMK MDW SS JC EHS. Conceived and designed the experiments: DMJ-D MY NCO GJD SS JC EHS. Performed the experiments: DMJ-D MY ER NCO GJD JL AMK MDW SS. Analyzed the data: DMJ-D MY GJD SS. Contributed reagents/materials/analysis tools: GJD SS JC EHS. Wrote the paper: DJD MY SS JC EHS.