About the Authors

Atanas G. Atanasov

Contributed equally to this work with: Atanas G. Atanasov, Martina Blunder, Nanang Fakhrudin, Verena M. Dirsch, Rudolf Bauer

atanas.atanasov@univie.ac.at

Affiliation Department of Pharmacognosy, University of Vienna, Vienna, Austria

Martina Blunder

Contributed equally to this work with: Atanas G. Atanasov, Martina Blunder, Nanang Fakhrudin, Verena M. Dirsch, Rudolf Bauer

Affiliation Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-University Graz, Graz, Austria

Nanang Fakhrudin

Contributed equally to this work with: Atanas G. Atanasov, Martina Blunder, Nanang Fakhrudin, Verena M. Dirsch, Rudolf Bauer

Affiliations Department of Pharmacognosy, University of Vienna, Vienna, Austria, Department of Pharmaceutical Biology, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia

Xin Liu

Affiliation Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-University Graz, Graz, Austria

Stefan M. Noha

Affiliation Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

Clemens Malainer

Affiliation Department of Pharmacognosy, University of Vienna, Vienna, Austria

Matthias P. Kramer

Affiliation Department of Pharmacognosy, University of Vienna, Vienna, Austria

Amina Cocic

Affiliation Department of Pharmacognosy, University of Vienna, Vienna, Austria

Olaf Kunert

Affiliation Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Karl-Franzens-University Graz, Graz, Austria

Andreas Schinkovitz

Affiliation Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-University Graz, Graz, Austria

Elke H. Heiss

Affiliation Department of Pharmacognosy, University of Vienna, Vienna, Austria

Daniela Schuster

Affiliation Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

Verena M. Dirsch

Contributed equally to this work with: Atanas G. Atanasov, Martina Blunder, Nanang Fakhrudin, Verena M. Dirsch, Rudolf Bauer

These authors also contributed equally to this work.

Affiliation Department of Pharmacognosy, University of Vienna, Vienna, Austria

Rudolf Bauer

Contributed equally to this work with: Atanas G. Atanasov, Martina Blunder, Nanang Fakhrudin, Verena M. Dirsch, Rudolf Bauer

These authors also contributed equally to this work.

Affiliation Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-University Graz, Graz, Austria

Competing Interests

Inte:Ligand GmbH provided LigandScout free of charge for this project. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AGA MB NF XL SMN CM MPK AC OK AS EHH DS VMD RB. Performed the experiments: AGA MB NF XL SMN CM MPK AC OK AS EHH. Analyzed the data: AGA MB NF XL SMN CM MPK OK AS EHH DS VMD RB. Wrote the paper: AGA MB NF XL SMN.