About the Authors

Hai Zhang

Contributed equally to this work with: Hai Zhang, Chenguang Wu

Affiliation Department of Molecular Pharmacology, Diabetes Research Center, Institute of Aging, Albert Einstein College of Medicine, Bronx, New York, United States of America

Chenguang Wu

Contributed equally to this work with: Hai Zhang, Chenguang Wu

Affiliation Department of Medicine, Endocrine Division, the Affiliated People’s Hospital of Jiangsu University, Jiangsu Province, Zhenjiang, P. R. China

Qiaofen Chen

Affiliation Department of Medicine, Endocrine Division, the Affiliated People’s Hospital of Jiangsu University, Jiangsu Province, Zhenjiang, P. R. China

Xiaoluo Chen

Affiliation Department of Medicine, Endocrine Division, the Affiliated People’s Hospital of Jiangsu University, Jiangsu Province, Zhenjiang, P. R. China

Zhigang Xu

Affiliation Department of Medicine, Endocrine Division, the Affiliated People’s Hospital of Jiangsu University, Jiangsu Province, Zhenjiang, P. R. China

Jing Wu

Affiliation Department of Medicine, Endocrine Division, the Affiliated People’s Hospital of Jiangsu University, Jiangsu Province, Zhenjiang, P. R. China

Dongsheng Cai

dongsheng.cai@einstein.yu.edu

Affiliation Department of Molecular Pharmacology, Diabetes Research Center, Institute of Aging, Albert Einstein College of Medicine, Bronx, New York, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflict: Some findings in this work have been submitted for US Provisional Patent #61/694,487. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DC. Performed the experiments: HZ CW QC XC ZX JW. Analyzed the data: HZ DC. Contributed reagents/materials/analysis tools: DC. Wrote the paper: DC.