About the Authors

Barbara A. Rath

Barbara.Rath@gmail.com

Affiliations Department of Pediatrics, Division of Pneumonology-Immunology, Charité University Medical Center, Berlin, Germany, Center for AIDS Research, Stanford University Medical Center, Stanford, California, United States of America

Kaveh Pouran Yousef

Affiliation Department of Mathematics and Computer Science, Free University, Berlin, Germany

David K. Katzenstein

Affiliation Center for AIDS Research, Stanford University Medical Center, Stanford, California, United States of America

Robert W. Shafer

Affiliation Center for AIDS Research, Stanford University Medical Center, Stanford, California, United States of America

Christof Schütte

Affiliation Department of Mathematics and Computer Science, Free University, Berlin, Germany

Max von Kleist

Affiliation Department of Mathematics and Computer Science, Free University, Berlin, Germany

Thomas C. Merigan

Affiliation Center for AIDS Research, Stanford University Medical Center, Stanford, California, United States of America

Competing Interests

Nevirapine (NVP) was provided by Boehringer Ingelheim (Ridgefield, CT), lamivudine (3 TC) by GlaxoSmithKline (Research Triangle Park, NC), and adefovir (ADV) by Gilead (Foster City, CA). These companies gave support in providing the respective drug preparations for the passage experiments. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TCM. Performed the experiments: BAR. Analyzed the data: BAR MvK KPY. Contributed reagents/materials/analysis tools: TCM DKK RWS MvK KPY CS. Wrote the paper: BAR MvK KPY. Conceived and designed the mathematical methods: MvK KPY CS. Provided important intellectual input to the manuscript: CS DKK RWS. Approved the final version of the manuscript: BAR KPY DKK RWS CS MvK TCM.