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Research Article

Functional Profiling of Precursor MicroRNAs Identifies MicroRNAs Essential for Glioma Proliferation

  • Saija Haapa-Paananen mail,

    saija.haapa-paananen@vtt.fi

    Affiliation: Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland

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  • Ping Chen,

    Affiliation: Computational Systems Biology Laboratory, Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland

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  • Kirsi Hellström,

    Affiliation: Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland

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  • Pekka Kohonen,

    Affiliation: Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland

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  • Sampsa Hautaniemi,

    Affiliation: Computational Systems Biology Laboratory, Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland

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  • Olli Kallioniemi,

    Affiliations: Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland, FIMM - Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

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  • Merja Perälä

    Affiliation: Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland

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  • Published: April 05, 2013
  • DOI: 10.1371/journal.pone.0060930

About the Authors

Saija Haapa-Paananen, Kirsi Hellström, Pekka Kohonen, Olli Kallioniemi, Merja Perälä
Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland
Ping Chen, Sampsa Hautaniemi
Computational Systems Biology Laboratory, Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
Olli Kallioniemi
FIMM - Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

Corresponding Author

Email: saija.haapa-paananen@vtt.fi

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SHP MP OK SH. Performed the experiments: SHP KH. Analyzed the data: SHP PK PC. Contributed reagents/materials/analysis tools: PC SH. Wrote the paper: SHP.