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Research Article

A COL11A2 Mutation in Labrador Retrievers with Mild Disproportionate Dwarfism

  • Mirjam Frischknecht,

    Affiliation: Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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  • Helena Niehof-Oellers,

    Affiliation: Düsseldorf, Germany

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  • Vidhya Jagannathan,

    Affiliation: Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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  • Marta Owczarek-Lipska,

    Affiliation: Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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  • Cord Drögemüller,

    Affiliation: Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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  • Elisabeth Dietschi,

    Affiliation: Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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  • Gaudenz Dolf,

    Affiliation: Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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  • Bernd Tellhelm,

    Affiliation: Department of Veterinary Clinical Science, Small Animal Clinic, Justus-Liebig-University, Giessen, Germany

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  • Johann Lang,

    Affiliation: Department of Clinical Veterinary Medicine, Division of Clinical Radiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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  • Katriina Tiira,

    Affiliations: Research Programs Unit, Molecular Medicine, University of Helsinki, Helsinki, Finland, Department of Veterinary Biosciences and Department of Medical Genetics, University of Helsinki, Helsinki, Finland, Folkhälsan Institute of Genetics, Helsinki, Finland

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  • Hannes Lohi,

    Affiliations: Research Programs Unit, Molecular Medicine, University of Helsinki, Helsinki, Finland, Department of Veterinary Biosciences and Department of Medical Genetics, University of Helsinki, Helsinki, Finland, Folkhälsan Institute of Genetics, Helsinki, Finland

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  • Tosso Leeb mail

    tosso.leeb@vetsuisse.unibe.ch

    Affiliation: Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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  • Published: March 20, 2013
  • DOI: 10.1371/journal.pone.0060149

About the Authors

Mirjam Frischknecht, Vidhya Jagannathan, Marta Owczarek-Lipska, Cord Drögemüller, Elisabeth Dietschi, Gaudenz Dolf, Tosso Leeb
Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Helena Niehof-Oellers
Düsseldorf, Germany
Bernd Tellhelm
Department of Veterinary Clinical Science, Small Animal Clinic, Justus-Liebig-University, Giessen, Germany
Johann Lang
Department of Clinical Veterinary Medicine, Division of Clinical Radiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Katriina Tiira, Hannes Lohi
Research Programs Unit, Molecular Medicine, University of Helsinki, Helsinki, Finland
Katriina Tiira, Hannes Lohi
Department of Veterinary Biosciences and Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Katriina Tiira, Hannes Lohi
Folkhälsan Institute of Genetics, Helsinki, Finland

Corresponding Author

Email: tosso.leeb@vetsuisse.unibe.ch

Competing Interests

H. Lohi owns shares of the company Genoscoper, which currently offers COL11A2 genotyping as a commercial genetic test. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MF TL. Performed the experiments: MF HN-O VJ MO-L CD BT. Analyzed the data: MF VJ CD GD JL TL. Contributed reagents/materials/analysis tools: HN-O ED BT KT HL. Wrote the paper: MF JL TL.