About the Authors

Brijal M. Desai

Contributed equally to this work with: Brijal M. Desai, Jessie Villanueva

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Jessie Villanueva

Contributed equally to this work with: Brijal M. Desai, Jessie Villanueva

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Thierry-Thien K. Nguyen

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Mercedes Lioni

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Min Xiao

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Jun Kong

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Clemens Krepler

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Adina Vultur

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Keith T. Flaherty

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America

Katherine L. Nathanson

Affiliation Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Keiran S. M. Smalley

Affiliation Department of Molecular Oncology, The Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

Meenhard Herlyn

herlynm@wistar.org

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors declare a financial competing interest in the form of a research grant from Schering-Plough, Kenilworth, New Jersey. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BMD JV TTKN ML MX KTF KLN KSMS MH. Performed the experiments: BMD JV TTKN ML MX JK KLN. Analyzed the data: BMD JV TTKN ML CK AV KLN KSMS. Contributed reagents/materials/analysis tools: KTF KLN MH. Wrote the paper: BMD JV CK AV KSMS KTF MH.