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Research Article

Prediction and Validation of Gene-Disease Associations Using Methods Inspired by Social Network Analyses

  • U. Martin Singh-Blom equal contributor,

    equal contributor Contributed equally to this work with: U. Martin Singh-Blom, Nagarajan Natarajan

    Affiliations: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas, United States of America, Department of Medicine, Karolinska Institutet, Solna, Stockholm, Sweden

    X
  • Nagarajan Natarajan equal contributor,

    equal contributor Contributed equally to this work with: U. Martin Singh-Blom, Nagarajan Natarajan

    Affiliation: Department of Computer Science. University of Texas, Austin, Texas, United States of America

    X
  • Ambuj Tewari,

    Affiliation: Department of Statistics. University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • John O. Woods,

    Affiliation: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas, United States of America

    X
  • Inderjit S. Dhillon mail,

    marcotte@mail.utexas.edu (EMM); inderjit@cs.utexas.edu (ISD)

    Affiliation: Department of Computer Science. University of Texas, Austin, Texas, United States of America

    X
  • Edward M. Marcotte mail

    marcotte@mail.utexas.edu (EMM); inderjit@cs.utexas.edu (ISD)

    Affiliations: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas, United States of America, Department of Chemistry and Biochemistry. University of Texas, Austin, Texas, United States of America

    X
  • Published: May 01, 2013
  • DOI: 10.1371/journal.pone.0058977

About the Authors

U. Martin Singh-Blom, John O. Woods, Edward M. Marcotte
Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas, United States of America
U. Martin Singh-Blom
Department of Medicine, Karolinska Institutet, Solna, Stockholm, Sweden
Nagarajan Natarajan, Inderjit S. Dhillon
Department of Computer Science. University of Texas, Austin, Texas, United States of America
Ambuj Tewari
Department of Statistics. University of Michigan, Ann Arbor, Michigan, United States of America
Edward M. Marcotte
Department of Chemistry and Biochemistry. University of Texas, Austin, Texas, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: UMS-B NN AT ISD EMM. Performed the experiments: UMS-B NN. Analyzed the data: UMS-B NN. Contributed reagents/materials/analysis tools: JOW. Wrote the paper: UMS-B NN AT ISD EMM.