Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial

Arash Hossein-nezhad; Avrum Spira; Michael F. Holick

doi:10.1371/journal.pone.0058725

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Open Access

Peer-reviewed

Research Article

Influence of Vitamin D Status and Vitamin D₃ Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial

Arash Hossein-nezhad,

Affiliation Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Avrum Spira,

Affiliation Department of Medicine, Section of Computational Biomedicine, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Michael F. Holick

* E-mail: mfholick@bu.edu

Affiliation Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯

Influence of Vitamin D Status and Vitamin D₃ Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial

Arash Hossein-nezhad,
Avrum Spira,
Michael F. Holick

Published: March 20, 2013
https://doi.org/10.1371/journal.pone.0058725

About the Authors

Arash Hossein-nezhad

Affiliation Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America

Avrum Spira

Affiliation Department of Medicine, Section of Computational Biomedicine, Boston University Medical Center, Boston, Massachusetts, United States of America

Michael F. Holick

* E-mail: mfholick@bu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AH MFH AS. Performed the experiments: AH MFH AS. Analyzed the data: AH MFH AS. Contributed reagents/materials/analysis tools: AH MFH AS. Wrote the paper: AH MFH AS.

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Vitamin D
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Vitamins
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Gene expression
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Gene regulation
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Vitamin D deficiency
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Sequence motif analysis
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Microarrays
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Micronutrient deficiencies
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