Advertisement
Research Article

Transcriptome Sequencing of Tumor Subpopulations Reveals a Spectrum of Therapeutic Options for Squamous Cell Lung Cancer

  • Christian L. Barrett,

    Affiliations: Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America, Department of Pediatrics and Rady Children's Hospital, University of California San Diego, La Jolla, California, United States of America

    X
  • Richard B. Schwab,

    Affiliations: Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America, Clinical and Translational Research Institute, University of California San Diego, La Jolla, California, United States of America

    X
  • HyunChul Jung,

    Affiliations: Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America, Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, California, United States of America

    X
  • Brian Crain,

    Affiliation: Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America

    X
  • Daniel J. Goff,

    Affiliation: Department of Medicine, Stem Cell and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

    X
  • Catriona H. M. Jamieson,

    Affiliation: Department of Medicine, Stem Cell and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

    X
  • Patricia A. Thistlethwaite,

    Affiliation: Division of Cardiothoracic Surgery, University of California San Diego, La Jolla, California, United States of America

    X
  • Olivier Harismendy,

    Affiliations: Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America, Department of Pediatrics and Rady Children's Hospital, University of California San Diego, La Jolla, California, United States of America, Clinical and Translational Research Institute, University of California San Diego, La Jolla, California, United States of America

    X
  • Dennis A. Carson,

    Affiliation: Sanford Consortium for Regenerative Medicine, La Jolla, California, United States of America

    X
  • Kelly A. Frazer mail

    kafrazer@ucsd.edu

    Affiliations: Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America, Department of Pediatrics and Rady Children's Hospital, University of California San Diego, La Jolla, California, United States of America, Clinical and Translational Research Institute, University of California San Diego, La Jolla, California, United States of America, Institute for Genomic Medicine, University of California San Diego, La Jolla, California, United States of America

    X
  • Published: March 20, 2013
  • DOI: 10.1371/journal.pone.0058714

About the Authors

Christian L. Barrett, Richard B. Schwab, HyunChul Jung, Brian Crain, Olivier Harismendy, Kelly A. Frazer
Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America
Christian L. Barrett, Olivier Harismendy, Kelly A. Frazer
Department of Pediatrics and Rady Children's Hospital, University of California San Diego, La Jolla, California, United States of America
HyunChul Jung
Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, California, United States of America
Richard B. Schwab, Olivier Harismendy, Kelly A. Frazer
Clinical and Translational Research Institute, University of California San Diego, La Jolla, California, United States of America
Patricia A. Thistlethwaite
Division of Cardiothoracic Surgery, University of California San Diego, La Jolla, California, United States of America
Kelly A. Frazer
Institute for Genomic Medicine, University of California San Diego, La Jolla, California, United States of America
Daniel J. Goff, Catriona H. M. Jamieson
Department of Medicine, Stem Cell and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America
Dennis A. Carson
Sanford Consortium for Regenerative Medicine, La Jolla, California, United States of America

Corresponding Author

Email: kafrazer@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CLB RBS DAC KAF. Performed the experiments: BC DJG PAT. Analyzed the data: CLB HJ OH KAF. Contributed reagents/materials/analysis tools: RBS CHMJ KAF. Wrote the paper: CLB KAF.