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Research Article

A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe

  • Andrey V. Khrunin mail,

    khrunin@img.ras.ru

    Affiliation: Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

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  • Denis V. Khokhrin,

    Affiliation: Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

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  • Irina N. Filippova,

    Affiliation: Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

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  • Tõnu Esko,

    Affiliations: Estonian Genome Center, University of Tartu, Tartu, Estonia, Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, Estonian Biocentre, Tartu, Estonia

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  • Mari Nelis,

    Affiliations: Estonian Genome Center, University of Tartu, Tartu, Estonia, Estonian Biocentre, Tartu, Estonia, Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

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  • Natalia A. Bebyakova,

    Affiliation: Deparment of Medical Biology and Genetics, Northern State Medical University, Archangelsk, Russia

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  • Natalia L. Bolotova,

    Affiliation: Deparment of Ecology and Zoology, Vologda State Pedagogical University, Vologda, Russia

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  • Janis Klovins,

    Affiliation: Latvian Biomedical Research and Study Centre, Riga, Latvia

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  • Liene Nikitina-Zake,

    Affiliation: Latvian Biomedical Research and Study Centre, Riga, Latvia

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  • Karola Rehnström,

    Affiliations: Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institiute, Hinxton, United Kingdom

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  • Samuli Ripatti,

    Affiliations: Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institiute, Hinxton, United Kingdom

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  • Stefan Schreiber,

    Affiliation: Department of Internal Medicine I, Popgen Biobank, Christian-Albrechts-University, Kiel, Germany

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  • Andre Franke,

    Affiliation: Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany

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  • Milan Macek,

    Affiliation: Department of Biology and Medical Genetics, University Hospital Motol and Second School of Medicine, Charles University Prague, Prague, Czech Republic

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  • Veronika Krulišová,

    Affiliation: Department of Biology and Medical Genetics, University Hospital Motol and Second School of Medicine, Charles University Prague, Prague, Czech Republic

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  • Jan Lubinski,

    Affiliation: Pomeranian Medical University, Szczecin, Poland

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  • Andres Metspalu,

    Affiliations: Estonian Genome Center, University of Tartu, Tartu, Estonia, Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, Estonian Biocentre, Tartu, Estonia

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  • Svetlana A. Limborska

    Affiliation: Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

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  • Published: March 07, 2013
  • DOI: 10.1371/journal.pone.0058552

About the Authors

Andrey V. Khrunin, Denis V. Khokhrin, Irina N. Filippova, Svetlana A. Limborska
Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia
Tõnu Esko, Mari Nelis, Andres Metspalu
Estonian Genome Center, University of Tartu, Tartu, Estonia
Tõnu Esko, Andres Metspalu
Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Tõnu Esko, Mari Nelis, Andres Metspalu
Estonian Biocentre, Tartu, Estonia
Mari Nelis
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
Natalia A. Bebyakova
Deparment of Medical Biology and Genetics, Northern State Medical University, Archangelsk, Russia
Natalia L. Bolotova
Deparment of Ecology and Zoology, Vologda State Pedagogical University, Vologda, Russia
Janis Klovins, Liene Nikitina-Zake
Latvian Biomedical Research and Study Centre, Riga, Latvia
Karola Rehnström, Samuli Ripatti
Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
Karola Rehnström, Samuli Ripatti
Wellcome Trust Sanger Institiute, Hinxton, United Kingdom
Stefan Schreiber
Department of Internal Medicine I, Popgen Biobank, Christian-Albrechts-University, Kiel, Germany
Andre Franke
Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany
Milan Macek, Veronika Krulišová
Department of Biology and Medical Genetics, University Hospital Motol and Second School of Medicine, Charles University Prague, Prague, Czech Republic
Jan Lubinski
Pomeranian Medical University, Szczecin, Poland

Corresponding Author

Email: khrunin@img.ras.ru

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AVK SAL. Performed the experiments: AVK DVK TE MN. Analyzed the data: AVK DVK INF TE. Contributed reagents/materials/analysis tools: TE MN NAB NLB JK LNZ KR SR SS AF MM VK JL AM SAL. Wrote the paper: AVK SAL.