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Research Article

Nano-Encapsulation of Arsenic Trioxide Enhances Efficacy against Murine Lymphoma Model while Minimizing Its Impact on Ovarian Reserve In Vitro and In Vivo

  • Richard W. Ahn equal contributor,

    equal contributor Contributed equally to this work with: Richard W. Ahn, Susan L. Barrett

    Affiliations: Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America

    X
  • Susan L. Barrett equal contributor,

    equal contributor Contributed equally to this work with: Richard W. Ahn, Susan L. Barrett

    Affiliations: Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, United States of America, Center for Reproductive Science Reproductive Biology Training Program, Northwestern University, Evanston, Illinois, United States of America

    X
  • Meera R. Raja,

    Affiliation: Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America

    X
  • Jennifer K. Jozefik,

    Affiliations: Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, United States of America

    X
  • Lidia Spaho,

    Affiliations: Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, United States of America

    X
  • Haimei Chen,

    Affiliations: Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America

    X
  • Marcel B. Bally,

    Affiliations: Centre for Drug Research and Development, University of British Columbia, Vancouver, British Columbia, Canada, Department of Advanced Therapeutics, BC Cancer Agency, British Columbia, Canada

    X
  • Andrew P. Mazar,

    Affiliations: Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America

    X
  • Michael J. Avram,

    Affiliations: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Department of Anesthesiology and Mary Beth Donnelley Clinical Pharmacology Core Facility of the Robert H. Lurie Comprehensive Cancer Center of the Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Jane N. Winter,

    Affiliations: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Department of Medicine, Division of Hematology/Oncology and Lymphoma Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Leo I. Gordon,

    Affiliations: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Department of Medicine, Division of Hematology/Oncology and Lymphoma Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Lonnie D. Shea,

    Affiliations: Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America, Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America

    X
  • Thomas V. O’Halloran mail,

    t-ohalloran@northwestern.edu (TVO); tkw@northwestern.edu (TKW)

    Affiliations: Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America

    X
  • Teresa K. Woodruff mail

    t-ohalloran@northwestern.edu (TVO); tkw@northwestern.edu (TKW)

    Affiliations: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, United States of America

    X
  • Published: March 20, 2013
  • DOI: 10.1371/journal.pone.0058491

About the Authors

Richard W. Ahn, Meera R. Raja, Haimei Chen, Andrew P. Mazar, Thomas V. O’Halloran
Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America
Richard W. Ahn, Haimei Chen, Andrew P. Mazar, Michael J. Avram, Jane N. Winter, Leo I. Gordon, Thomas V. O’Halloran, Teresa K. Woodruff
Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America
Richard W. Ahn, Susan L. Barrett, Jennifer K. Jozefik, Lidia Spaho, Haimei Chen, Lonnie D. Shea, Thomas V. O’Halloran, Teresa K. Woodruff
Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America
Susan L. Barrett, Jennifer K. Jozefik, Lidia Spaho, Teresa K. Woodruff
Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, United States of America
Susan L. Barrett
Center for Reproductive Science Reproductive Biology Training Program, Northwestern University, Evanston, Illinois, United States of America
Marcel B. Bally
Centre for Drug Research and Development, University of British Columbia, Vancouver, British Columbia, Canada
Michael J. Avram
Department of Anesthesiology and Mary Beth Donnelley Clinical Pharmacology Core Facility of the Robert H. Lurie Comprehensive Cancer Center of the Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
Jane N. Winter, Leo I. Gordon
Department of Medicine, Division of Hematology/Oncology and Lymphoma Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
Lonnie D. Shea
Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America
Marcel B. Bally
Department of Advanced Therapeutics, BC Cancer Agency, British Columbia, Canada

Corresponding Authors

Competing Interests

TVO and HC are inventors on a patent issued to Northwestern University which covers the NB(Ni,As). This agent is not currently in development and the patent does not alter the authors’ ability to adhere to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RWA SLB MRR JKJ LS HC MBB APM MJA JNW LIG LDS TVO TKW. Performed the experiments: RWA SLB MRR JKJ HC LS. Analyzed the data: RWA SLB MRR JKJ LS HC MBB APM MJA JNW LIG LDS TVO TKW. Contributed reagents/materials/analysis tools: MBB APM MJA JNW LIG LDS TVO TKW. Wrote the paper: RWA SLB TVO TKW.