About the Authors

Christian Wolf

Affiliation Clinical Development, Lycalis s.p.r.l., Brussels, Belgium

Jagdev Sidhu

Affiliation Clinical Pharmacology/Early Development, CSL Ltd., Melbourne, Australia

Christian Otoul

Affiliation Exploratory Statistics, UCB Pharma, Brabant, Belgium

Dexter L. Morris

tony.morris@ucb.com

Affiliation Drug Development, UCB Biosciences Inc., Raleigh, North Carolina, United States of America

Jennifer Cnops

Affiliation Department of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium

Jorg Taubel

Affiliation Richmond Pharmacology, London, United Kingdom

Barbara Bennett

Affiliation BABennett Consulting, Marietta, Georgia, United States of America

Competing Interests

This study was funded by UCB Pharma and Biogen Idec, which were jointly developing CDP323 as a potential treatment for multiple sclerosis. Dr. Morris has been an employee of and holds stock in GlaxoSmithKline and is currently employed by and has received stock options from UCB Biosciences Inc. Among my coauthors, Dr. Wolf was a salaried employee of UCB Pharma S.A. during the time the study was conducted and has been a consultant for Novartis and Synthon. Dr. Sidhu was a salaried employee of and received stock in UCB Pharma during the time the study was conducted. Dr. Otoul is an employee of UCB Pharma. Dr. Taubel is employed by Richmond Pharmacology, which received financial remuneration for their clinical involvement in this study. Dr. Bennett was a salaried employee of UCB Biosciences Inc. during the time the study was conducted and is now an independent consultant. Dr. Cnops reports no conflicts of interest. This does not alter the authors’ adherence to all of the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CW JS CO JT. Performed the experiments: JT. Analyzed the data: CW JS CO DLM JC JT BB. Wrote the paper: CW JS CO DLM JC JT BB.