About the Authors

David J. Dowling

Contributed equally to this work with: David J. Dowling, Zhen Tan

Affiliations Department of Medicine, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Zhen Tan

Contributed equally to this work with: David J. Dowling, Zhen Tan

Affiliations Department of Medicine, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pediatrics, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Zofia M. Prokopowicz

Affiliations Department of Medicine, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Christine D. Palmer

Affiliations Department of Medicine, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Maura-Ann H. Matthews

Affiliation VentiRx Pharmaceuticals, Inc., Seattle, Washington, United States of America

Gregory N. Dietsch

Affiliation VentiRx Pharmaceuticals, Inc., Seattle, Washington, United States of America

Robert M. Hershberg

Affiliation VentiRx Pharmaceuticals, Inc., Seattle, Washington, United States of America

Ofer Levy

ofer.levy@childrens.harvard.edu

Affiliations Department of Medicine, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

Maura-Ann Matthews, Gregory Dietsch, Robert Hershberg are employees of VentiRx Pharmaceuticals, Inc. The remaining authors have no financial conflict of interest. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Initiated and supervised the studies: OL. Conceived and designed the experiments: DJD. Performed the experiments: DJD ZT. Analyzed the data: DJD ZT CDP. Contributed reagents/materials/analysis tools: DJD ZT ZMP CDP GND MHM RMH. Wrote the paper: DJD.