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Research Article

Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas

  • Jenny M. Kreahling,

    Affiliation: Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

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  • Parastou Foroutan,

    Affiliation: Department of Cancer Imaging Research, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

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  • Damon Reed,

    Affiliations: Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America, Sarcoma Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

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  • Gary Martinez,

    Affiliation: Department of Cancer Imaging Research, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

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  • Tiffany Razabdouski,

    Affiliation: Department of Comparative Medicine, University of South Florida, Tampa, Florida, United States of America

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  • Marilyn M. Bui,

    Affiliations: Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America, Sarcoma Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

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  • Meera Raghavan,

    Affiliation: Department of Diagnostic Imaging and Sarcoma, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

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  • Douglas Letson,

    Affiliation: Sarcoma Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

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  • Robert J. Gillies,

    Affiliation: Department of Cancer Imaging Research, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

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  • Soner Altiok mail

    soner.altiok@moffitt.org

    Affiliations: Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America, Sarcoma Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

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  • Published: March 08, 2013
  • DOI: 10.1371/journal.pone.0057523

About the Authors

Jenny M. Kreahling, Damon Reed, Marilyn M. Bui, Soner Altiok
Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
Parastou Foroutan, Gary Martinez, Robert J. Gillies
Department of Cancer Imaging Research, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
Meera Raghavan
Department of Diagnostic Imaging and Sarcoma, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
Damon Reed, Marilyn M. Bui, Douglas Letson, Soner Altiok
Sarcoma Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
Tiffany Razabdouski
Department of Comparative Medicine, University of South Florida, Tampa, Florida, United States of America

Corresponding Author

Email: soner.altiok@moffitt.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMK SA. Performed the experiments: JMK PF. Analyzed the data: JMK PF. Contributed reagents/materials/analysis tools: PF MMB MR TR GM DL RJG. Wrote the paper: JMK PF DR SA.