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Research Article

Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process

  • Jessica I. Gold,

    Affiliation: Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Jeffrey S. Martini,

    Affiliation: Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Jonathan Hullmann,

    Affiliation: Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Erhe Gao,

    Affiliation: Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • J. Kurt Chuprun,

    Affiliation: Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Linda Lee,

    Affiliation: Department of Pharmacology, University of California Davis, Davis, California, United States of America

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  • Douglas G. Tilley,

    Affiliations: Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Joseph E. Rabinowitz,

    Affiliations: Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Julie Bossuyt,

    Affiliation: Department of Pharmacology, University of California Davis, Davis, California, United States of America

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  • Donald M. Bers,

    Affiliation: Department of Pharmacology, University of California Davis, Davis, California, United States of America

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  • Walter J. Koch mail

    Walter.Koch@temple.edu

    Affiliations: Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: March 05, 2013
  • DOI: 10.1371/journal.pone.0057324

About the Authors

Jessica I. Gold, Jeffrey S. Martini, Jonathan Hullmann, Walter J. Koch
Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Erhe Gao, J. Kurt Chuprun, Douglas G. Tilley, Joseph E. Rabinowitz, Walter J. Koch
Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
Douglas G. Tilley, Joseph E. Rabinowitz, Walter J. Koch
Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
Linda Lee, Julie Bossuyt, Donald M. Bers
Department of Pharmacology, University of California Davis, Davis, California, United States of America

Corresponding Author

Email: Walter.Koch@temple.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JIG JSM JKC JB DMB WJK. Performed the experiments: JIG JSM EG LL. Analyzed the data: JIG DGT JB. Contributed reagents/materials/analysis tools: JIG JH JKC DGT JER JB. Wrote the paper: JIG WJK.