About the Authors

Ai-Luen Wu

Contributed equally to this work with: Ai-Luen Wu, Bo Feng, Mark Z. Chen

Affiliation Department of Molecular Biology, Genentech, Inc., South San Francisco, California, United States of America

Bo Feng

Contributed equally to this work with: Ai-Luen Wu, Bo Feng, Mark Z. Chen

Affiliation Department of Molecular Biology, Genentech, Inc., South San Francisco, California, United States of America

Mark Z. Chen

Contributed equally to this work with: Ai-Luen Wu, Bo Feng, Mark Z. Chen

Affiliation Department of Molecular Biology, Genentech, Inc., South San Francisco, California, United States of America

Ganesh Kolumam

Affiliation Biomedical Imaging, Genentech, Inc., South San Francisco, California, United States of America

Jose Zavala-Solorio

Affiliation Biomedical Imaging, Genentech, Inc., South San Francisco, California, United States of America

Shelby K. Wyatt

Affiliation Biomedical Imaging, Genentech, Inc., South San Francisco, California, United States of America

Vineela D. Gandham

Affiliation Biomedical Imaging, Genentech, Inc., South San Francisco, California, United States of America

Richard A. D. Carano

Affiliation Biomedical Imaging, Genentech, Inc., South San Francisco, California, United States of America

Junichiro Sonoda

junichis@gene.com

Affiliation Department of Molecular Biology, Genentech, Inc., South San Francisco, California, United States of America

Competing Interests

The authors have the following competing interest: Ai-Luen Wu, Bo Feng, Ganesh Kolumam, Jose Zavala-Solorio, Shelby K. Wyatt, Vineela D. Gandham, Richard A. D. Carano, and Junichiro Sonoda were employees of Genentech, Inc. at the time this work was conducted. The affiliations with Genentech, Inc. do not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ALW BF MZC GK JZS SKW VDG RADC JS. Performed the experiments: ALW BF MZC GK JZS SKW VDG JS. Analyzed the data: ALW BF MZC GK JZS SKW VDG RADC JS. Contributed reagents/materials/analysis tools: ALW BF MZC SKW VDG RADC JS. Wrote the paper: JS.