About the Authors

Eri Ohfuchi Maruyama

Contributed equally to this work with: Eri Ohfuchi Maruyama, H-M. Ivy Yu

Affiliation Department of Biomedical Genetics, Center for Oral Biology, James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, United States of America

H-M. Ivy Yu

Contributed equally to this work with: Eri Ohfuchi Maruyama, H-M. Ivy Yu

Affiliation Department of Biomedical Genetics, Center for Oral Biology, James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, United States of America

Ming Jiang

Affiliation Department of Biomedical Genetics, Center for Oral Biology, James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, United States of America

Jiang Fu

Affiliation Department of Biomedical Genetics, Center for Oral Biology, James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, United States of America

Wei Hsu

Wei_Hsu@urmc.rochester.edu

Affiliation Department of Biomedical Genetics, Center for Oral Biology, James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, United States of America

Competing Interests

A patent application (PCT/US12/52270; Title: Modulating Wnt activity by targeting Gpr177) relating to this manuscript has been filed. The authors declare their adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EOM HIY MJ JF WH. Performed the experiments: EOM HIY MJ JF. Analyzed the data: EOM HIY MJ JF WH. Wrote the paper: EOM HIY WH.