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Research Article

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

  • Sebastiano Collino mail,

    sebastiano.collino@rd.nestle.com

    Affiliation: Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Ivan Montoliu,

    Affiliation: Applied Mathematics, NESTEC SA, Nestlé Research Center, Lausanne, Switzerland

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  • François-Pierre J. Martin,

    Affiliation: Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Max Scherer,

    Affiliation: Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Daniela Mari,

    Affiliations: Department of Medical Sciences, University of Milan, Milan, Italy, Geriatric Unit Ca' Grande Foundation Maggiore Policlinico Hospital, Milan, Italy

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  • Stefano Salvioli,

    Affiliations: Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Laura Bucci,

    Affiliations: Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Rita Ostan,

    Affiliations: Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Daniela Monti,

    Affiliation: Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy

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  • Elena Biagi,

    Affiliation: Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

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  • Patrizia Brigidi,

    Affiliation: Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

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  • Claudio Franceschi,

    Affiliations: Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Serge Rezzi

    Affiliation: Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Published: March 06, 2013
  • DOI: 10.1371/journal.pone.0056564

About the Authors

Sebastiano Collino, François-Pierre J. Martin, Max Scherer, Serge Rezzi
Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland
Ivan Montoliu
Applied Mathematics, NESTEC SA, Nestlé Research Center, Lausanne, Switzerland
Daniela Mari
Department of Medical Sciences, University of Milan, Milan, Italy
Daniela Mari
Geriatric Unit Ca' Grande Foundation Maggiore Policlinico Hospital, Milan, Italy
Stefano Salvioli, Laura Bucci, Rita Ostan, Claudio Franceschi
Department of Experimental Pathology, University of Bologna, Bologna, Italy
Stefano Salvioli, Laura Bucci, Rita Ostan, Claudio Franceschi
Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy
Daniela Monti
Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy
Elena Biagi, Patrizia Brigidi
Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

Corresponding Author

Email: sebastiano.collino@rd.nestle.com

Competing Interests

Authors SC, FPM, MS, SR are employees of Nestlè Institute of Health Science SA. Author IM is an employee of Nestec S.A. There are no products in development or marketed products to declare. Five patents were filed based on the results presented in the paper. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Performed the initial gut microbiota studies: EB PB. Provided samples from Down's Syndrome subjects: SS. Provided the aging cohort samples: D. Mari. Conceived and designed the experiments: CF. Performed the experiments: SC MS. Analyzed the data: FPM IM D. Monti LB RO. Contributed reagents/materials/analysis tools: MS. Wrote the paper: SC CF SR.