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Research Article

High-Fidelity Tissue Engineering of Patient-Specific Auricles for Reconstruction of Pediatric Microtia and Other Auricular Deformities

  • Alyssa J. Reiffel mail,

    Jas2037@med.cornell.edu

    Affiliation: Laboratory for Bioregenerative Medicine and Surgery, Division of Plastic Surgery, Weill Cornell Medical College, New York, New York, United States of America

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  • Concepcion Kafka,

    Affiliation: Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

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  • Karina A. Hernandez,

    Affiliation: Laboratory for Bioregenerative Medicine and Surgery, Division of Plastic Surgery, Weill Cornell Medical College, New York, New York, United States of America

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  • Samantha Popa,

    Affiliation: Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

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  • Justin L. Perez,

    Affiliation: Laboratory for Bioregenerative Medicine and Surgery, Division of Plastic Surgery, Weill Cornell Medical College, New York, New York, United States of America

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  • Sherry Zhou,

    Affiliation: Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

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  • Satadru Pramanik,

    Affiliation: Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

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  • Bryan N. Brown,

    Affiliations: Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America, Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Won Seuk Ryu,

    Affiliation: Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

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  • Lawrence J. Bonassar,

    Affiliation: Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America

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  • Jason A. Spector

    Affiliation: Laboratory for Bioregenerative Medicine and Surgery, Division of Plastic Surgery, Weill Cornell Medical College, New York, New York, United States of America

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  • Published: February 20, 2013
  • DOI: 10.1371/journal.pone.0056506

About the Authors

Alyssa J. Reiffel, Karina A. Hernandez, Justin L. Perez, Jason A. Spector
Laboratory for Bioregenerative Medicine and Surgery, Division of Plastic Surgery, Weill Cornell Medical College, New York, New York, United States of America
Concepcion Kafka, Samantha Popa, Sherry Zhou, Satadru Pramanik, Bryan N. Brown, Won Seuk Ryu, Lawrence J. Bonassar
Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America
Bryan N. Brown
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Corresponding Author

Email: Jas2037@med.cornell.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AJR BNB LJB JAS. Performed the experiments: AJR CK KAH S. Popa JLP SZ S. Pramanik BNB WSR. Analyzed the data: AJR CK KAH S. Popa JLP SZ S. Pramanik BNB WSR LJB JAS. Contributed reagents/materials/analysis tools: LJB JAS. Wrote the paper: AJR CK KAH S. Popa JLP SZ S. Pramanik BNB WSR LJB JAS.