About the Authors

Blanca E. Himes

blanca.himes@channing.harvard.edu

Affiliations Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Children’s Hospital Informatics Program, Boston, Massachusetts, United States of America, Partners HealthCare Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America

Keith Sheppard

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America

Annerose Berndt

Affiliation Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Adriana S. Leme

Affiliation Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Rachel A. Myers

Affiliation Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

Christopher R. Gignoux

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Albert M. Levin

Affiliation Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, United States of America

W. James Gauderman

Affiliation Department of Preventative Medicine, University of Southern California, Los Angeles, California, United States of America

James J. Yang

Affiliation Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, United States of America

Rasika A. Mathias

Affiliation Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Isabelle Romieu

Affiliation International Agency for Research on Cancer (IARC), Lyon, France

Dara G. Torgerson

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Lindsey A. Roth

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Scott Huntsman

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Celeste Eng

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Barbara Klanderman

Affiliation Partners HealthCare Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America

John Ziniti

Affiliation Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Jody Senter-Sylvia

Affiliation Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Stanley J. Szefler

Affiliation National Jewish Health and University of Colorado Denver School of Medicine, Denver, Colorado, United States of America

Robert F. Lemanske Jr

Affiliation University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Robert S. Zeiger

Affiliation Kaiser Permanente Southern California Region, San Diego, California, United States of America and University of California San Diego, La Jolla, California, United States of America

Robert C. Strunk

Affiliation Washington University School of Medicine, St. Louis, Missouri, United States of America

Fernando D. Martinez

Affiliation Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson, Arizona, United States of America

Homer Boushey

Affiliation Division of Pulmonary/Critical Care and Allergy/Immunology, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Vernon M. Chinchilli

Affiliation Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania, United States of America

Elliot Israel

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

David Mauger

Affiliation Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania, United States of America

Gerard H. Koppelman

Affiliation Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children’s Hospital, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Dirkje S. Postma

Affiliation Department of Pulmonology and Tuberculosis, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Maartje A. E. Nieuwenhuis

Affiliation Department of Pulmonology and Tuberculosis, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Judith M. Vonk

Affiliation Department of Epidemiology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

John J. Lima

Affiliation Nemours Children's Clinic, Center for Pharmacogenomics and Translational Research, Jacksonville, Florida, United States of America

Charles G. Irvin

Affiliation Vermont Lung Center, Department of Medicine and Physiology, University of Vermont, Burlington, Vermont, United States of America

Stephen P. Peters

Affiliation Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Michiaki Kubo

Affiliation RIKEN Center for Genomic Medicine, Kanagawa, Japan

Mayumi Tamari

Affiliation RIKEN Center for Genomic Medicine, Kanagawa, Japan

Yusuke Nakamura

Affiliation Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Augusto A. Litonjua

Affiliation Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Kelan G. Tantisira

Affiliation Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Benjamin A. Raby

Affiliation Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Eugene R. Bleecker

Affiliation Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Deborah A. Meyers

Affiliation Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Stephanie J. London

Affiliation National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

Kathleen C. Barnes

Affiliation Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Frank D. Gilliland

Affiliation Department of Preventative Medicine, University of Southern California, Los Angeles, California, United States of America

L. Keoki Williams

Affiliation Center for Health Policy and Health Services Research, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, United States of America

Esteban G. Burchard

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Dan L. Nicolae

Affiliation Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

Carole Ober

Affiliation Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

Dawn L. DeMeo

Affiliation Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Edwin K. Silverman

Affiliation Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Beverly Paigen

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America

Gary Churchill

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America

Steve D. Shapiro

Affiliation Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Scott T. Weiss

Affiliations Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Partners HealthCare Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Collected subjects for and designed human GWAS: SJS RFL RSZ RCS FDM HB VMC EI DM DSP JJL CGI SPP AAL KGT BAR ERB DAM SJL KCB FDG LKW EGB DLN CO. Analyzed human GWAS data: BEH RAM CRG AML WJG JJY RAM IR DGT LAR SH CE BK JZ JS GHK MAEN JMV. Collected genotype data for Sepracor, LOCCS, and LODO: MK MT YN. Conceived and designed the experiments: BEH DLD EKS BP GC SDS STW. Performed the experiments: AB ASL. Analyzed the data: BEH KS AB ASL. Wrote the paper: BEH SJS RSZ DSP DLD EKS GC STW.