About the Authors
- Hiroshi Yamamoto
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Contributed equally to this work with: Hiroshi Yamamoto, Kazuhisa Maeda
Affiliation Department of Surgery, Shiga University of Medical Science, Shiga, Japan
- Kazuhisa Maeda
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Contributed equally to this work with: Hiroshi Yamamoto, Kazuhisa Maeda
* E-mail: maedakazu@aol.com
Affiliation Department of Complementary & Alternative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
- Yoshitaka Uji
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Affiliation Department of Surgery, Shiga University of Medical Science, Shiga, Japan
- Hiroshi Tsuchihashi
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Affiliation Department of Surgery, Shiga University of Medical Science, Shiga, Japan
- Tsuyoshi Mori
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Affiliation Department of Surgery, Shiga University of Medical Science, Shiga, Japan
- Tomoharu Shimizu
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Affiliation Department of Surgery, Shiga University of Medical Science, Shiga, Japan
- Yoshihiro Endo
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Affiliation Department of Surgery, Shiga University of Medical Science, Shiga, Japan
- Aya Kadota
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Affiliation Department of Health Science, Shiga University of Medical Science, Shiga, Japan
- Katsuyuki Miura
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Affiliation Department of Health Science, Shiga University of Medical Science, Shiga, Japan
- Yusuke Koga
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Affiliation Department of Complementary & Alternative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
- Toshinori Ito
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Affiliation Department of Complementary & Alternative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
- Tohru Tani
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Affiliation Department of Surgery, Shiga University of Medical Science, Shiga, Japan
Competing Interests
This work was supported by Grant-in-Aid for Scientific Research (C), a grant of the Knowledge Cluster Initiative implemented by the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), and also, in part, by a grant from Otsuka Pharmaceutical Co., Ltd. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Developed the concept of ADN as a stress marker: HY K. Maeda. Management of patients: HY TT. Received research support from Otsuka Pharmaceutical Co., Ltd: HY. Conceived and designed the experiments: HY K. Maeda TT. Performed the experiments: YU HT TM YE. Analyzed the data: HY AK K. Miura. Contributed reagents/materials/analysis tools: YU HT TM TS HY AK K. Miura. Wrote the paper: HY K. Maeda YK TI.