About the Authors

Theodora Szasz

iszasz@georgiahealth.edu

Affiliation Department of Physiology, Georgia Health Sciences University, Augusta, Georgia, United States of America

Robert Patrick Davis

Affiliation Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America

Hannah S. Garver

Affiliation Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America

Robert J. Burnett

Affiliation Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America

Gregory D. Fink

Affiliation Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America

Stephanie W. Watts

Affiliation Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America

Competing Interests

Financial support was provided by Takeda Pharmaceuticals U.S.A., Inc. in the form of a research grant (#MSA-FEB-134) and the study drug (febuxostat). Febuxostat is a product of Takeda Pharmaceuticals U.S.A., Inc. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: TS GDF SWW. Performed the experiments: TS RPD HSG RJB SWW. Analyzed the data: TS RJB SWW. Contributed reagents/materials/analysis tools: GDF SWW. Wrote the paper: TS SWW.