About the Authors

Alexander W. Drong

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

George Nicholson

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

Åsa K. Hedman

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Eshwar Meduri

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Elin Grundberg

Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Department of Twin Research, King's College London, London, United Kingdom

Kerrin S. Small

Affiliation Department of Twin Research, King's College London, London, United Kingdom

So-Youn Shin

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Jordana T. Bell

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Twin Research, King's College London, London, United Kingdom

Fredrik Karpe

Affiliation Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

Nicole Soranzo

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Tim D. Spector

Affiliation Department of Twin Research, King's College London, London, United Kingdom

Mark I. McCarthy

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

Panos Deloukas

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Mattias Rantalainen

Contributed equally to this work with: Mattias Rantalainen, Cecilia M. Lindgren

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

Cecilia M. Lindgren

Contributed equally to this work with: Mattias Rantalainen, Cecilia M. Lindgren

celi@well.ox.ac.uk

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

on behalf of the MolPAGE Consortia

Competing Interests

This work was supported by the Wellcome Trust (090532/Z/09/Z) and the European Community's Sixth Framework Programme, MolPAGE Consortium (LSHG-CT-2004-512066), which included both academic and commercial partners. The latter, included Epigenomics AG, whose involvement in MolPAGE was funded on a 50/50 basis. Epigenomics took no patents on the work and has no active products in the field of diabetes and obesity. None of the authors own stocks or shares of Epigenomics AG, are employed or members of the board of Epigenomics AG, or have received research grants, travel grants, or any gifts of any kind from Epigenomics AG. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials. AWD is a Wellcome Trust Student (093933Z/10/Z). JTB was funded by a Sir Henry Wellcome Trust postdoctoral fellowship. NS is supported by the Wellcome Trust (Core Grant Number 091746/Z/10/Z). PD is supported by the Wellcome Trust core grant 098051 which also covered costs for methylation profiling with the 27K methylation array, carried out by the Genotyping Facility at the Wellcome Trust Sanger Institute. MR is a MRC biomedical informatics fellow (Medical Research Council, fellowship G0802460). CML is a Wellcome Trust Research Career Development Fellow (086596/Z/08/Z).

Author Contributions

Conceived and designed the experiments: FK NS TDS MIM PD MR CML. Performed the experiments: AWD EM. Analyzed the data: AWD GN AKH EM. Contributed reagents/materials/analysis tools: EG KSS SYS JTB. Wrote the paper: AWD AKH SYS MR CML.