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Research Article

Integrated MicroRNA and mRNA Signatures Associated with Survival in Triple Negative Breast Cancer

  • Luciano Cascione equal contributor,

    equal contributor Contributed equally to this work with: Luciano Cascione, Pierluigi Gasparini

    Affiliations: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America, Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy

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  • Pierluigi Gasparini equal contributor,

    equal contributor Contributed equally to this work with: Luciano Cascione, Pierluigi Gasparini

    Affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America

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  • Francesca Lovat,

    Affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America

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  • Stefania Carasi,

    Affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America

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  • Alfredo Pulvirenti,

    Affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy

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  • Alfredo Ferro,

    Affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy

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  • Hansjuerg Alder,

    Affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America

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  • Gang He,

    Affiliation: Department of Pathology, Ohio State University Wexner Medical Center, Division of Pathology II, Columbus, Ohio, United States of America

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  • Andrea Vecchione,

    Affiliations: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America, University of Rome “La Sapienza”, Ospedale Santo Andrea, Rome, Italy

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  • Carlo M. Croce,

    Affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America

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  • Charles L. Shapiro ,

    Affiliation: Division of Medical Oncology and the Breast Program James Cancer Hospital and Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America

    These authors also contributed equally to this work.

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  • Kay Huebner mail

    kay.huebner@osumc.edu

    Affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America

    These authors also contributed equally to this work.

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  • Published: February 06, 2013
  • DOI: 10.1371/journal.pone.0055910

About the Authors

Luciano Cascione, Pierluigi Gasparini, Francesca Lovat, Stefania Carasi, Hansjuerg Alder, Andrea Vecchione, Carlo M. Croce, Kay Huebner
Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America
Luciano Cascione, Alfredo Pulvirenti, Alfredo Ferro
Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy
Gang He
Department of Pathology, Ohio State University Wexner Medical Center, Division of Pathology II, Columbus, Ohio, United States of America
Andrea Vecchione
University of Rome “La Sapienza”, Ospedale Santo Andrea, Rome, Italy
Charles L. Shapiro
Division of Medical Oncology and the Breast Program James Cancer Hospital and Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America

Corresponding Author

Email: kay.huebner@osumc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Edited the MS: FL LC CLS SC. Coordination of tissue collection and clinical databases: CLS. Conceived and designed the experiments: KH CLS PG. Performed the experiments: GH PG FL SC. Analyzed the data: LC AP AF. Contributed reagents/materials/analysis tools: HA AV CMC. Wrote the paper: KH PG.