About the Authors
- Molly Plovanich
-
Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America
- Roman L. Bogorad
-
Affiliation Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
- Yasemin Sancak
-
Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America
- Kimberli J. Kamer
-
Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America
- Laura Strittmatter
-
Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America
- Andrew A. Li
-
Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America
- Hany S. Girgis
-
Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America
- Satya Kuchimanchi
-
Affiliation Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America
- Jack De Groot
-
Affiliation Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America
- Lauren Speciner
-
Affiliation Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America
- Nathan Taneja
-
Affiliation Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America
- Jonathan OShea
-
Affiliation Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America
- Victor Koteliansky
-
Affiliation Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
- Vamsi K. Mootha
-
* E-mail: vamsi@hms.harvard.edu
Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America
Competing Interests
Please note that in this paper, the authors' academic laboratory (based at Massachusetts General Hospital/Harvard Medical School) collaborated with Alnylam Pharmaceuticals (co-authors include JDG, L. Speciner, NT, JO, VK). As employees, they received compensation/stock from Alnylam. The authors do not believe that the fact that they are employees of a company, receiving salary/equity from this company, represents a competing interest that compromises the objectivity of the work. This does not alter the authors' adherence to all the PLOS ONE policies on data sharing and materials.
Author Contributions
Performed computational analysis: AAL. Designed, validated and produced siRNA reagents: RLB SK JDG L. Speciner NT JO VK. Conceived and designed the experiments: MP VKM RLB YS KJK L. Strittmatter HSG. Performed the experiments: MP RLB YS KJK L. Strittmatter HSG. Analyzed the data: MP RLB YS KJK L. Strittmatter HSG. Wrote the paper: MP VKM.