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Research Article

Candidate Sequence Variants and Fetal Hemoglobin in Children with Sickle Cell Disease Treated with Hydroxyurea

  • Nancy S. Green mail,

    nsg11@columbia.edu

    Affiliation: Department of Pediatrics, Columbia University, New York, New York, United States of America

    X
  • Katherine L. Ender,

    Affiliation: Department of Pediatrics, Columbia University, New York, New York, United States of America

    X
  • Farzana Pashankar,

    Affiliation: Department of Pediatrics, Yale University, New Haven, Connecticut, United States of America

    X
  • Catherine Driscoll,

    Affiliation: Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America

    X
  • Patricia J. Giardina,

    Affiliation: Department of Pediatrics, Weill Cornell University Medical School, New York, New York, United States of America

    X
  • Craig A. Mullen,

    Affiliation: Department of Pediatrics, University of Rochester, Rochester, New York, United States of America

    X
  • Lorraine N. Clark,

    Affiliation: Department of Pathology and Cell Biology, Columbia University, New York, New York, United States of America

    X
  • Deepa Manwani,

    Affiliation: Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America

    X
  • Jennifer Crotty,

    Affiliation: Department of Pediatrics, Columbia University, New York, New York, United States of America

    X
  • Sergey Kisselev,

    Affiliation: Department of Pathology and Cell Biology, Columbia University, New York, New York, United States of America

    X
  • Kathleen A. Neville,

    Affiliation: Department of Pediatrics, Children’s Mercy Hospitals and Clinics, Kansas City, Missouri, United States of America

    X
  • Carolyn Hoppe,

    Affiliation: Department of Hematology-Oncology, Children’s Hospital and Research Center Oakland, Oakland, California, United States of America

    X
  • Sandra Barral

    Affiliation: G. H. Sergievsky Center, Columbia University, New York, New York, United States of America

    X
  • Published: February 07, 2013
  • DOI: 10.1371/journal.pone.0055709

About the Authors

Nancy S. Green, Katherine L. Ender, Jennifer Crotty
Department of Pediatrics, Columbia University, New York, New York, United States of America
Farzana Pashankar
Department of Pediatrics, Yale University, New Haven, Connecticut, United States of America
Catherine Driscoll, Deepa Manwani
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America
Patricia J. Giardina
Department of Pediatrics, Weill Cornell University Medical School, New York, New York, United States of America
Craig A. Mullen
Department of Pediatrics, University of Rochester, Rochester, New York, United States of America
Lorraine N. Clark, Sergey Kisselev
Department of Pathology and Cell Biology, Columbia University, New York, New York, United States of America
Kathleen A. Neville
Department of Pediatrics, Children’s Mercy Hospitals and Clinics, Kansas City, Missouri, United States of America
Carolyn Hoppe
Department of Hematology-Oncology, Children’s Hospital and Research Center Oakland, Oakland, California, United States of America
Sandra Barral
G. H. Sergievsky Center, Columbia University, New York, New York, United States of America

Corresponding Author

Email: nsg11@columbia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NSG KLE SB. Performed the experiments: NSG KLE FP CD PJG CAM LNC DM JC SK KAN CH SB. Analyzed the data: NSG KLE LC SK SB. Contributed reagents/materials/analysis tools: NSG KLE FP CD PJG CAM LNC DM JC SK KAN CH SB. Wrote the paper: NSG KLE CAM LNC SB.